MW 305.4 Da, Purity >98%. Vanilloid receptor (VR1) agonist (pEC50 values are 7.5 and 6.1 at human and rat VR1 receptors, respectively). Antinociceptive and anti-inflammatory effects mediated by primary afferent sensory neurones. Induces reversible inhibition of platelet aggregation.
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- EBioMedicine 84:1042582022Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhongyang Lv,Jie Han,Jiawei Li,Hu Guo,Yuxiang Fei,Ziying Sun,Jian Dong,Maochun Wang,Chunmei Fan,Weitong Li,Ya Xie,Wei Sun,Jiaqi Chen,Yuan Liu,Fufei Chen,Zizheng Liu,Anlong Liu,Rui Wu,Xingquan Xu,Wenjin Yan,Qing Jiang,Shiro Ikegawa,Xiao Chen,Dongquan ShiPubMed 36137413
- Frontiers in medicine 9:8208172022Dramatic Effect of Botulinum Toxin Type A on Hypertrophic Scar: A Promising Therapeutic Drug and Its Mechanism Through the SP-NK1R Pathway in Cutaneous Neurogenic Inflammation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShunuo Zhang,Ke Li,Zhixi Yu,Jun Chai,Zheng Zhang,Yixin Zhang,Peiru MinPubMed 35308522
- Cell death & disease 12:5042021TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca/CaMKII/Nrf2 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhongyang Lv,Xingquan Xu,Ziying Sun,Yannick Xiaofan Yang,Hu Guo,Jiawei Li,Kuoyang Sun,Rui Wu,Jia Xu,Qing Jiang,Shiro Ikegawa,Dongquan ShiPubMed 34006826
- The Journal of neuroscience : the official journal 39:9702-97152019The NGF Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGiovanna Testa et. al.PubMed 31685654
- Molecules (Basel, Switzerland) 21:2016Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKaiyu Qian et. al.PubMed 27775662
Key facts
- CAS number
- 7553-53-9
- Purity
- > 98%
- Form
- Solid
- Source
- Capsicum sp.
- Molecular weight
- 305.4 Da
- Molecular formula
- C18H27NO3
- PubChem identifier
- 2548
- Nature
- Native
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MW 305.4 Da, Purity >98%. Vanilloid receptor (VR1) agonist (pEC50 values are 7.5 and 6.1 at human and rat VR1 receptors, respectively). Antinociceptive and anti-inflammatory effects mediated by primary afferent sensory neurones. Induces reversible inhibition of platelet aggregation.
Key facts
- CAS number
- 7553-53-9
- Purity
- > 98%
- Form
- Solid
- Source
- Capsicum sp.
- Molecular weight
- 305.4 Da
- Molecular formula
- C18H27NO3
- PubChem identifier
- 2548
- Nature
- Native
- Solubility
Soluble in DMSO to 50 mM.
Soluble in ethanol to 50 mM.
- Biochemical name
- N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
- Biological description
Vanilloid receptor (VR1) agonist (pEC50 values are 7.5 and 6.1 at human and rat VR1 receptors, respectively). Antinociceptive and anti-inflammatory effects mediated by primary afferent sensory neurones. Induces reversible inhibition of platelet aggregation.
- Canonical SMILES
- CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
- InChI
- InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)
- InChIKey
- YKPUWZUDDOIDPM-UHFFFAOYSA-N
- IUPAC name
- N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
Notes
This product is manufactured by BioVision, an Abcam company and was previously called 2521 Capsaicin. 2521-250 is the same size as the 250 mg size of ab141000.
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2 product images
Chemical Structure - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
2D chemical structure image of ab141000, (E)-Capsaicin, Vanilloid receptor agonist
Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (ab141000)
Capsaicin induces Ca2+ influx via activation of TRPV1 channels expressed in C6 cells. Cells were loaded with Fluo-3 AM (Fluo-3 AM, Fluorescent calcium Indicator ab145254) and stimulated with Capsaicin (ab141000). Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application. The left panel shows normalized fluorescence before and after application (at 20 seconds) of 0-10 µM Capsaicin (as indicated). The right panel shows normalized fluorescence plotted against Capsaicin concentrations.
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