JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141000

(E)-Capsaicin, Vanilloid receptor agonist

Be the first to review this product! Submit a review

|

(6 Publications)

MW 305.4 Da, Purity >98%. Vanilloid receptor (VR1) agonist (pEC50 values are 7.5 and 6.1 at human and rat VR1 receptors, respectively). Antinociceptive and anti-inflammatory effects mediated by primary afferent sensory neurones. Induces reversible inhibition of platelet aggregation.
2 Images
Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (AB141000)
  • FuncS

Unknown

Functional Studies - (E)-Capsaicin, Vanilloid receptor agonist (AB141000)

Capsaicin induces Ca2+ influx via activation of TRPV1 channels expressed in C6 cells. Cells were loaded with Fluo-3 AM (ab145254) and stimulated with Capsaicin (ab141000). Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application. The left panel shows normalized fluorescence before and after application (at 20 seconds) of 0-10 µM Capsaicin (as indicated). The right panel shows normalized fluorescence plotted against Capsaicin concentrations.

Chemical Structure - (E)-Capsaicin, Vanilloid receptor agonist (AB141000)
  • Chemical Structure

Lab

Chemical Structure - (E)-Capsaicin, Vanilloid receptor agonist (AB141000)

2D chemical structure image of ab141000, (E)-Capsaicin, Vanilloid receptor agonist

Key facts

CAS number

7553-53-9

Purity

>98%

Form

Solid

form

Source

Capsicum sp.

Molecular weight

305.4 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>7</sub>NO<sub>3</sub>

PubChem

2548

Nature

Native

Solubility

Soluble in DMSO to 50 mM

Soluble in ethanol to 50 mM

Biochemical name

N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Biological description

Vanilloid receptor (VR1) agonist (pEC50 values are 7.5 and 6.1 at human and rat VR1 receptors, respectively). Antinociceptive and anti-inflammatory effects mediated by primary afferent sensory neurones. Induces reversible inhibition of platelet aggregation.

Canonical smiles

CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC

InChi

InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)

InChiKey

YKPUWZUDDOIDPM-UHFFFAOYSA-N

IUPAC Name

N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide

style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2521 Capsaicin. 2521-250 is the same size as the 250 mg size of ab141000.
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

International journal of ophthalmology 17:420-434 PubMed38721513

2024

Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca-dependent AMPK/mTOR pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liu-Hui Huang,Jiao Lyu,Sheng Chen,Ting-Yi Liang,Yu-Qing Rao,Ping Fei,Jing Li,Hai-Ying Jin,Pei-Quan Zhao

EBioMedicine 84:104258 PubMed36137413

2022

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyang Lv,Jie Han,Jiawei Li,Hu Guo,Yuxiang Fei,Ziying Sun,Jian Dong,Maochun Wang,Chunmei Fan,Weitong Li,Ya Xie,Wei Sun,Jiaqi Chen,Yuan Liu,Fufei Chen,Zizheng Liu,Anlong Liu,Rui Wu,Xingquan Xu,Wenjin Yan,Qing Jiang,Shiro Ikegawa,Xiao Chen,Dongquan Shi

Frontiers in medicine 9:820817 PubMed35308522

2022

Dramatic Effect of Botulinum Toxin Type A on Hypertrophic Scar: A Promising Therapeutic Drug and Its Mechanism Through the SP-NK1R Pathway in Cutaneous Neurogenic Inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Shunuo Zhang,Ke Li,Zhixi Yu,Jun Chai,Zheng Zhang,Yixin Zhang,Peiru Min

Cell death & disease 12:504 PubMed34006826

2021

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca/CaMKII/Nrf2 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyang Lv,Xingquan Xu,Ziying Sun,Yannick Xiaofan Yang,Hu Guo,Jiawei Li,Kuoyang Sun,Rui Wu,Jia Xu,Qing Jiang,Shiro Ikegawa,Dongquan Shi

The Journal of neuroscience : the official journal 39:9702-9715 PubMed31685654

2019

The NGF Mutation Specifically Impairs Nociception without Affecting Cognitive Performance in a Mouse Model of Hereditary Sensory and Autonomic Neuropathy Type V.

Applications

Unspecified application

Species

Unspecified reactive species

Giovanna Testa,Marco Mainardi,Chiara Morelli,Francesco Olimpico,Laura Pancrazi,Carla Petrella,Cinzia Severini,Rita Florio,Francesca Malerba,Antonia Stefanov,Enrica Strettoi,Rossella Brandi,Ivan Arisi,Paul Heppenstall,Mario Costa,Simona Capsoni,Antonino Cattaneo

Molecules (Basel, Switzerland) 21: PubMed27775662

2016

Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiyu Qian,Gang Wang,Rui Cao,Tao Liu,Guofeng Qian,Xinyuan Guan,Zhongqiang Guo,Yu Xiao,Xinghuan Wang
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Biochemicals

AB120003

D-AP5, NMDA glutamate site antagonist

Chemical Structure - D-AP5, NMDA glutamate site antagonist (AB120003)

  • 0
  • 0
Biochemicals

AB120286

Thapsigargin, Ca2+-ATPase inhibitor

Functional Studies - Thapsigargin, Ca2+-ATPase inhibitor (AB120286)

  • 5
  • 1

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com