Echinomycin, HIF-1alpha inhibitor

Be the first to review this product! Submit a review

|

(2 Publications)

MW 1101.3 Da, Purity >98%. Potent, reversible cell-permeable HIF-1α inhibitor (EC₅₀ = 1.2 nM, hypoxia-induced HIF-1 transcription activity in U215 cells). Specifically intercalates into DNA. Antibacterial, antiviral, antiangiogenic and antitumor effects in vivo. .

View Alternative Names

BLM_HUMAN, BS, Bloom syndrome, Bloom syndrome RecQ helicase like, Bloom syndrome protein, DINB protein, DINB1, DINP, DKFZp686C2056, DNA damage inducible protein b, DNA helicase, DNA helicase RecQ like type 2, DNA helicase, RecQ like type 3, DNA polymerase eta, DNA polymerase iota, DNA polymerase kappa, DNase IV, DinB homolog 1 (E. coli), Eta 2, Exonuclease WRN, FEN1_HUMAN, FLJ16395, FLJ21978, Flap endonuclease 1, Flap structure-specific endonuclease 1, HGNC 12791, MF1, MGC126616, MGC131618, MGC131620, Maturation factor 1, NF-E2-related factor 2, NF2L2_HUMAN, NRF2, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, OTTHUMP00000225301, POLH_HUMAN, POLI_HUMAN, POLK_HUMAN, POLQ, Polymerase (DNA directed) iota, Polymerase (DNA directed) kappa, RAD 30B, RAD30, RAD30 homolog A, RAD30 homolog B, RAD30, S. cerevisiae, homolog of, RAD30A, RAD3OB, RECQ 2, RECQ like, RECQL 2, RECQL 3, Rad2, RecQ protein-like 2, RecQ protein-like 3, RecQ-like type 2, RecQ-like type 3, RecQ3, WRN_HUMAN, Werner syndrome ATP-dependent helicase, Werner syndrome helicase, Werner syndrome protein, Werner syndrome, RecQ helicase like, XP V, Xeroderma pigmentosum variant type protein, erythroid derived 2, hFEN-1, like 2, nuclear factor erythroid 2 like 2, polymerase DNA directed eta, polymerase, DNA, kappa, type 2