MW 252.22 Da, Purity >98%. Thymidine analog. Alternative to BrdU (5-Bromo-2'-deoxyuridine) (ab142567) for measuring de novo DNA synthesis during S-phase. Cytotoxic anti-metabolite. Used for probing short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.
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- Cell metabolism 35:472-486.e62023Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel I Benjamin,Jamie O Brett,Pieter Both,Joel S Benjamin,Heather L Ishak,Jengmin Kang,Soochi Kim,Mingyu Chung,Marina Arjona,Christopher W Nutter,Jenna H Tan,Ananya K Krishnan,Hunter Dulay,Sharon M Louie,Antoine de Morree,Daniel K Nomura,Thomas A RandoPubMed 36854304
- iScience 25:1053022022Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmrita Sharma,Michael Cipriano,Lori Ferrins,Stephen L Hajduk,Kojo Mensa-WilmotPubMed 36304107
- Development (Cambridge, England) 149:2022Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuyi Mai,Xiaoxuan Zhu,Esther Yi Ching Wan,Shengyu Wu,Jesslyn Nagalin Yonathan,Jun Wang,Ying Li,Jessica Yuen Wuen Ma,Bing Zuo,Dennis Yan-Yin Tse,Pui-Chi Lo,Xin Wang,Kui Ming Chan,David M Wu,Wenjun XiongPubMed 35833708
- Development (Cambridge, England) :2022Postnatal eye size in mice is controlled by SREBP2-mediated transcriptional repression of Lrp2 and Bmp2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShuyi Mai,Xiaoxuan Zhu,Esther Yi Ching Wan,Shengyu Wu,Jesslyn Nagalin Yonathan,Jun Wang,Ying Li,Jessica Yuen Wuen Ma,Bing Zuo,Dennis Yan-Yin Tse,Pui-Chi Lo,Xin Wang,Kui Ming Chan,David M Wu,Wenjun XiongPubMed 35831947
- Cell metabolism 34:902-918.e62022Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel I Benjamin,Pieter Both,Joel S Benjamin,Christopher W Nutter,Jenna H Tan,Jengmin Kang,Leo A Machado,Julian D D Klein,Antoine de Morree,Soochi Kim,Ling Liu,Hunter Dulay,Ludovica Feraboli,Sharon M Louie,Daniel K Nomura,Thomas A RandoPubMed 35584694
- Cell reports 39:1107742022Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDiego Sainz de la Maza,Silvana Hof-Michel,Lee Phillimore,Christian Bökel,Marc AmoyelPubMed 35545055
- Evidence-based complementary and alternative medicine : eCAM 2022:39454462022FAM117A Is a New Prognostic Marker of Lung Adenocarcinoma and Predicts Sensitivity to PD0332991.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChao Wu,Jiajin Zhang,Kuan Wang,Mengjiao Fan,Yi HuPubMed 35280504
- Cell reports 35:1090982021Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElisia D Tichy,Nuoying Ma,David Sidibe,Emanuele Loro,Jacob Kocan,Delia Z Chen,Tejvir S Khurana,Paul Hasty,Foteini MourkiotiPubMed 33979621
- Nature communications 12:27612021A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLouciné Mitoyan,Véronique Chevrier,Hector Hernandez-Vargas,Alexane Ollivier,Zeinab Homayed,Julie Pannequin,Flora Poizat,Cécile De Biasi-Cador,Emmanuelle Charafe-Jauffret,Christophe Ginestier,Géraldine GuaschPubMed 33980830
- Developmental cell 56:1014-1029.e72021Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDaniel C L Robinson,Morten Ritso,Geoffrey M Nelson,Zeinab Mokhtari,Kiran Nakka,Hina Bandukwala,Seth R Goldman,Peter J Park,Rémi Mounier,Bénédicte Chazaud,Marjorie Brand,Michael A Rudnicki,Karen Adelman,F Jeffrey DilworthPubMed 33735618
Key facts
- CAS number
61135-33-9
- Purity
> 98%
- Form
Solid
- Molecular weight
252.22 Da
- Molecular formula
C11H12N2O5
- PubChem identifier
472172
- Nature
Synthetic
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MW 252.22 Da, Purity >98%. Thymidine analog. Alternative to BrdU (5-Bromo-2'-deoxyuridine) (ab142567) for measuring de novo DNA synthesis during S-phase. Cytotoxic anti-metabolite. Used for probing short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.
Key facts
- CAS number
61135-33-9
- Purity
> 98%
- Form
Solid
- Molecular weight
252.22 Da
- Molecular formula
C11H12N2O5
- PubChem identifier
472172
- Nature
Synthetic
- Solubility
Soluble in water to 10 mM. Soluble in DMSO to 100 mM.
- Biochemical name
5-Ethynyl-2'-deoxyuridine
- Biological description
Thymidine analog. Alternative to BrdU (5-Bromo-2'-deoxyuridine) (ab142567) for measuring de novo DNA synthesis during S-phase. Cytotoxic anti-metabolite. Used for probing short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.
- Canonical SMILES
C#CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
- Isomeric SMILES
C#CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
- InChI
InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1
- InChIKey
CDEURGJCGCHYFH-DJLDLDEBSA-N
- IUPAC name
5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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Chemical Structure - EdU, DNA synthesis monitoring probe (ab146186)
2D chemical structure image of ab146186, EdU, DNA synthesis monitoring probe
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