Skip to main content

MW 447.9 Da, Purity >99%. Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC50 = 0.7 nM), HIV 2 EHO (IC50 = 2.8 nM) and HIV-2 ROD (IC50 = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC50 range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.

Be the first to review this product! Submit a review

Images

Chemical Structure - Elvitegravir, quinolone HIV integrase inhibitor (AB231510), expandable thumbnail

Key facts

CAS number
697761-98-1
Purity
> 99%
Form
Solid
Molecular weight
447.9 Da
Molecular formula
C23H23ClFNO5
PubChem identifier
5277135
Nature
Synthetic

Target data

Recommended products

MW 447.9 Da, Purity >99%. Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC50 = 0.7 nM), HIV 2 EHO (IC50 = 2.8 nM) and HIV-2 ROD (IC50 = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC50 range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.

Key facts

Purity
> 99%
PubChem identifier
5277135
Solubility

Soluble in DMSO to 10mg/ml.

Soluble in dimethyl formamide to 20mg/ml.

Biochemical name
Elvitegravir
Biological description

Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC50 = 0.7 nM), HIV 2 EHO (IC50 = 2.8 nM) and HIV-2 ROD (IC50 = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC50 range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.

Canonical SMILES
CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O
Isomeric SMILES
CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O
InChI
InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1
InChIKey
JUZYLCPPVHEVSV-LJQANCHMSA-N
IUPAC name
6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - Elvitegravir, quinolone HIV integrase inhibitor (ab231510), expandable thumbnail

    Chemical Structure - Elvitegravir, quinolone HIV integrase inhibitor (ab231510)

    2D chemical structure image of ab231510, Elvitegravir, quinolone HIV integrase inhibitor

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com