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AB231510

Elvitegravir, quinolone HIV integrase inhibitor

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MW 447.9 Da, Purity >99%. Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC50 = 0.7 nM), HIV 2 EHO (IC50 = 2.8 nM) and HIV-2 ROD (IC50 = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC50 range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.
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Chemical Structure - Elvitegravir, quinolone HIV integrase inhibitor (AB231510)
  • Chemical Structure

Lab

Chemical Structure - Elvitegravir, quinolone HIV integrase inhibitor (AB231510)

2D chemical structure image of ab231510, Elvitegravir, quinolone HIV integrase inhibitor

Key facts

CAS number

697761-98-1

Purity

>99%

Form

Solid

form

Molecular weight

447.9 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>3</sub>ClFNO<sub>5</sub>

PubChem

5277135

Nature

Synthetic

Solubility

Soluble in DMSO to 10mg/ml

Soluble in dimethyl formamide to 20mg/ml

Biochemical name

Elvitegravir

Biological description

Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC50 = 0.7 nM), HIV 2 EHO (IC50 = 2.8 nM) and HIV-2 ROD (IC50 = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC50 range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.

Canonical smiles

CC(C)C(CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O

Isomeric smiles

CC(C)[C@@H](CO)N1C=C(C(=O)C2=C1C=C(C(=C2)CC3=C(C(=CC=C3)Cl)F)OC)C(=O)O

InChi

InChI=1S/C23H23ClFNO5/c1-12(2)19(11-27)26-10-16(23(29)30)22(28)15-8-14(20(31-3)9-18(15)26)7-13-5-4-6-17(24)21(13)25/h4-6,8-10,12,19,27H,7,11H2,1-3H3,(H,29,30)/t19-/m1/s1

InChiKey

JUZYLCPPVHEVSV-LJQANCHMSA-N

IUPAC Name

6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid

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Complementary Products

Biochemicals

AB120124

2-APB, Ca2+ release modulator

Functional Studies - 2-APB, Ca2+ release modulator (AB120124)

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Primary Antibodies

AB32352

Anti-HIV1 p24 antibody [P131]

RabMAb|Recombinant

Western blot - Anti-HIV1 p24 antibody [P131] (AB32352)

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Assay Kits

AB218268

HIV1 p24 ELISA Kit

SimpleStep

Sandwich ELISA - HIV1 p24 ELISA Kit (AB218268)

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Proteins & Peptides

AB310318

Recombinant HIV1 Gag protein (His-tag)

Mass Spectrometry - Recombinant HIV1 Gag protein (His-tag) (AB310318)

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Product promise

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