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AB120328

EMD 386088 hydrochloride, 5-HT6 agonist

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(1 Publication)

MW 283.2 Da, Purity >98%. Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory *in vivo*.
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Chemical Structure - EMD 386088 hydrochloride, 5-HT6 agonist (AB120328)
  • Chemical Structure

Lab

Chemical Structure - EMD 386088 hydrochloride, 5-HT6 agonist (AB120328)

2D chemical structure image of ab120328, EMD 386088 hydrochloride, 5-HT6 agonist

Key facts

CAS number

1171123-46-8

Purity

>98%

Form

Solid

form

Molecular weight

283.2 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>

PubChem

56972198

Nature

Synthetic

Solubility

Soluble in water to 25 mM (with heating)

Soluble in DMSO to 100 mM

Biochemical name

Emd 386088 hydrochloride

Biological description

Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory *in vivo*.

Canonical smiles

CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3.Cl

InChi

InChI=1S/C14H15ClN2.ClH/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9;/h2-4,8,16-17H,5-7H2,1H3;1H

InChiKey

WWSNDUWIZDYGIQ-UHFFFAOYSA-N

IUPAC Name

5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of psychopharmacology (Oxford, England) 27:469-76 PubMed23479455

2013

The 5-hydroxytryptamine (serotonin) receptor 6 agonist EMD 386088 ameliorates ketamine-induced deficits in attentional set shifting and novel object recognition, but not in the prepulse inhibition in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Agnieszka Nikiforuk,Katarzyna Fijał,Agnieszka Potasiewicz,Piotr Popik,Tomasz Kos
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