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AB141454

Emodin, 11beta-HSD1 inhibitor

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MW 270.24 Da, Purity >98%. Potent, selective 11β-HSD1 inhibitor (IC50 values are 186 and 86 nM for human and mouse 11beta-HSD1 respectively). Antioxidant agent. Activates caspase-3, -8 and -9. Increases Bax and decreases Bcl-2. Antidyslipidemic *in vivo.* Orally active.

View Alternative Names

Atherosclerosis, susceptibility to, included, CK II, CK II alpha, CK II alpha', CK II beta, CK2A1, CK2A2, CK2B, CK2N, CSK21_HUMAN, CSK22_HUMAN, CSK2B_HUMAN, CSNK 2B, Casein kinase 2 alpha prime polypeptide, Casein kinase 2 beta polypeptide, Casein kinase II alpha chain, Casein kinase II alpha' chain, Casein kinase II beta subunit, Casein kinase II subunit alpha, Casein kinase II subunit alpha', Casein kinase II subunit beta, Casein kinase II, alpha 1 polypeptide, Casein kinase II, alpha 1 related sequence 4, Csnk2a1-rs4, DKFZp686N23123, ER, ER-alpha, ER-beta, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESR2_HUMAN, ESRA, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta, Estrogen receptor beta 4, Estrogen resistance, included, FLJ43934, G5A, HD 7, HD 7B, HD 9, HDAC, HDAC 7B, HDAC 9B, HDAC 9FL, HDAC9_HUMAN, HDL cholesterol, augmented response of, to hormone replacement, included, HDRP, Histone deacetylase 4/5 related protein, Histone deacetylase 7, Histone deacetylase 7B, Histone deacetylase 9, Histone deacetylase 9A, Histone deacetylase-related protein, KIAA0744, MEF2 interacting transcription repressor protein, MEF2-interacting transcription repressor MITR, MGC102141, MGC138222, MGC138224, MITR, Myocardial infarction, susceptibility to, included, NR3A1, NR3A2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, OTTHUMP00000017718, OTTHUMP00000017719, OTTMUSP00000016898;, Phosvitin, Protein G5a, RNESTROR, RP23-452D3.3, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b

1 Images
Chemical Structure - Emodin, 11beta-HSD1 inhibitor (AB141454)
  • Chemical Structure

Lab

Chemical Structure - Emodin, 11beta-HSD1 inhibitor (AB141454)

2D chemical structure image of ab141454, Emodin, 11beta-HSD1 inhibitor

Key facts

CAS number

518-82-1

Purity

>98%

Form

Solid

form

Molecular weight

270.24 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>0</sub>O<sub>5</sub>

PubChem

3220

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Emodin

Biological description

Potent, selective 11β-HSD1 inhibitor (IC50 values are 186 and 86 nM for human and mouse 11beta-HSD1 respectively). Antioxidant agent. Activates caspase-3, -8 and -9. Increases Bax and decreases Bcl-2. Antidyslipidemic *in vivo.* Orally active.

Canonical smiles

CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O

InChi

InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3

InChiKey

RHMXXJGYXNZAPX-UHFFFAOYSA-N

IUPAC Name

1,3,8-trihydroxy-6-methylanthracene-9,10-dione

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 1875 Emodin. 1875-100 is the same size as the 100 mg size of ab141454.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Estrogen Receptor (ER) family which includes Estrogen Receptor beta (ERβ) is a group of nuclear receptors activated by the hormone estrogen. These receptors often referred to simply as ER or ERβ for short have a molecular mass of around 65-70 kDa. They are predominantly expressed in tissues such as the breast prostate ovary and brain. In addition to estrogen receptors Casein Kinase 2 alpha (CSNK2A2) and beta subunits are important too both forming the Casein Kinase 2 (CK2) holoenzyme. CK2 is ubiquitously expressed and known for its serine/threonine kinase activity. Histone deacetylase 9 (HDAC9) is another target involved in chromatin remodeling and gene expression primarily expressed in the brain and muscle tissue.
Biological function summary

Estrogen Receptors play significant roles in gene transcription regulation and modulate the growth and function of tissues responsive to steroid hormones. They usually act as dimers and can form complexes with other proteins to activate or repress transcription. CK2 which consists of two alpha subunits (like CSNK2A2) and two regulatory beta subunits phosphorylates various target proteins affecting cellular processes like cell cycle control. HDAC9 regulates chromatin structure by removing acetyl groups from histone proteins thereby influencing gene expression patterns. Collectively these proteins contribute to diverse cellular functions impacting development homeostasis and response to environmental stimuli.

Pathways

These proteins integrate into multiple signaling cascades. Estrogen Receptors are key components of the hormone signaling pathway impacting the expression of genes involved in reproductive tissue function and development. They are related to proteins such as CREB and AP1 which also mediate gene expression. CK2 associates with the Wnt signaling pathway affecting cellular dynamics and proliferation. It interacts with proteins like β-catenin playing a part in oncogenic processes. HDAC9 participates in the regulation of the Notch signaling pathway connecting to proteins like NICD (Notch intracellular domain) which are important for determining cell fate and differentiation.

Estrogen Receptor dysregulation often links to breast and prostate cancers due to its critical function in cell proliferation. Aberrant ER signaling can lead to hormone-dependent tumor growth interacting with proteins such as HER2. CK2 has associations with cancer as well specifically chronic lymphocytic leukemia due to its role in cell survival and apoptosis. The CSNK2A2 subunit influences pathways instrumental in cancer progression. HDAC9 dysregulation is connected to cardiac hypertrophy with changes impacting cardiac myocyte function. HDAC9-associated disorders often involve interplay with MEF2 proteins which control muscle gene expression and differentiation.
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Product protocols

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