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AB141699

ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist

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(3 Publications)

MW 283.41 Da, Purity >99%. Selective protease-activated receptor 2 (PAR2) antagonist (IC50 = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.
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Chemical Structure - ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist (AB141699)
  • Chemical Structure

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Chemical Structure - ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist (AB141699)

2D chemical structure image of ab141699, ENMD-1068, protease-activated receptor 2 (PAR2) anatagonist

Key facts

CAS number

789488-77-3

Purity

>99%

Form

Solid

form

Molecular weight

283.41 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>9</sub>N<sub>3</sub>O<sub>2</sub>

PubChem

9950925

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

6-Amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one

Biological description

Selective protease-activated receptor 2 (PAR2) antagonist (IC50 = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.

Canonical smiles

CC(C)CC(=O)N1CCN(CC1)C(=O)CCCCCN

InChi

InChI=1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3

InChiKey

VRZYMMVEALDDBH-UHFFFAOYSA-N

IUPAC Name

6-amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Clinical and translational medicine 15:e70291 PubMed40147022

2025

The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing.

Applications

Unspecified application

Species

Unspecified reactive species

Na Zhao,Guojian Wang,Shuang Long,Xiaofan Lv,Xinze Ran,Junping Wang,Yongping Su,Tao Wang

American journal of cancer research 9:1995-2006 PubMed31598400

2019

Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoli Zhang,Qing Fang,Yiming Ma,Shuangmei Zou,Qian Liu,Hongying Wang

Pain 155:1328-38 PubMed24726923

2014

Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Kenny Roman,Joseph D Done,Anthony J Schaeffer,Stephen F Murphy,Praveen Thumbikat
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Secondary Antibodies

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Primary Antibodies

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