Eplerenone, Selective mineralocorticoid antagonist
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(1 Publication)
MW 414.5 Da, Purity >99%. Selective mineralocorticoid (aldosterone) antagonist (IC50 = 81 nM). Significantly greater selectivity than spironolactone at androgen, progesterone and glucocorticoid receptors. Antihypertensive, orally active in vivo.
View Alternative Names
AIS, ANDR_HUMAN, AR, AR8, Aldosterone receptor, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor, testicular feminization, spinal and bulbar muscular atrophy, Kennedy disease), DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), GCCR, GCRST, GCR_HUMAN, GR, Glucocorticoid receptor, Grl1, HUMARA, HYSP1, KD, Kennedy disease (KD), MCR_HUMAN, MGC133092, MLR, MR, Mineralocorticoid receptor, NR3 C2, NR3C2 protein, NR3C3, NR3C4, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 2, Nuclear receptor subfamily 3 group C member 3, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), PGR, PR, PRA, PRB, PRGR_HUMAN, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, SBMA, SMAX1, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), TFM, Testicular Feminization (TFM), androgen receptor splice variant 4b, glucocorticoid nuclear receptor variant 1, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Chemical Structure
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Chemical Structure - Eplerenone, Selective mineralocorticoid antagonist (AB141251)
2D chemical structure image of ab141251, Eplerenone, Selective mineralocorticoid antagonist
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Properties and storage information
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Handling instructions
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Toxic, refer to SDS for further information.
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These receptors play critical roles in regulating numerous physiological processes. They are involved in complex interactions with cofactors and DNA to influence transcription. GR regulates stress responses and immune function. PR plays a role in the menstrual cycle and pregnancy while MR maintains electrolyte balance. AR influences male sexual development and metabolic processes. These receptors form part of larger complexes that modify chromatin and facilitate gene transcription in response to specific hormones.
Pathways
These receptors integrate into vital hormonal signaling pathways. The GR is important in the hypothalamic-pituitary-adrenal (HPA) axis interacting with HSP90 and other chaperone proteins for proper folding and activity. The PR functions in reproductive hormone signaling interacting with pathways that include the Estrogen Receptor (ER). These pathways are intricately connected ensuring fine regulation of hormone actions and cross-talk between different hormonal signals.
Publications (1)
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Scientific reports 14:9976 PubMed38693148
2024
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