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AB141271

Epothilone B, Microtubule stabilizing agent

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(2 Publications)

MW 507.7 Da, Purity >98%. Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.
1 Images
Chemical Structure - Epothilone B, Microtubule stabilizing agent (AB141271)
  • Chemical Structure

Lab

Chemical Structure - Epothilone B, Microtubule stabilizing agent (AB141271)

2D chemical structure image of ab141271, Epothilone B, Microtubule stabilizing agent

Key facts

CAS number

152044-54-7

Purity

>98%

Form

Solid

form

Molecular weight

507.7 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>4</sub><sub>1</sub>NO<sub>6</sub>S

PubChem

448013

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

Epothilone B

Biological description

Microtubule-stabilizing agent. Analog of Epothilone A and D (ab143615 and ab143616). Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel (ab120143)-resistant cell lines. Shows antitumor effects in vivo. Orally active.

Canonical smiles

CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C

Isomeric smiles

C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

InChi

InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

InChiKey

QXRSDHAAWVKZLJ-PVYNADRNSA-N

IUPAC Name

(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

AB144290

Latrunculin A (LAT-A), Actin polymerization inhibitor

Chemical Structure - Latrunculin A (LAT-A), Actin polymerization inhibitor (AB144290)

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  • 0
Secondary Antibodies

AB150121

Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgM mu chain (Alexa Fluor® 488) (AB150121)

  • 5
  • 5
Primary Antibodies

AB270400

Anti-PMP22 antibody [EPR23112-110]

BOND RX™ Validated|RabMAb|Recombinant|Trial Size

Western blot - Anti-PMP22 antibody [EPR23112-110] (AB270400)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PMP22 also known as Peripheral Myelin Protein 22 is a critical membrane protein involved in the myelination process within the peripheral nervous system. This protein has a mass of approximately 22 kDa. PMP22 is produced mainly in Schwann cells which are responsible for the formation of myelin sheaths around nerve fibers. It plays a role in maintaining the structural integrity and function of these myelin sheaths.
Biological function summary

PMP22 contributes to the regulation of cell growth and apoptosis ensuring proper nerve function and repair. It is not usually part of larger protein complexes but interacts significantly with myelin-associated proteins to stabilize the nerve structure. The protein also supports the adhesion among Schwann cells which helps in maintaining the compactness of the myelin sheath.

Pathways

PMP22 engages primarily in the myelination pathway and is essential for neuronal signaling. It interacts with proteins like MPZ (Myelin Protein Zero) which also takes part in myelin sheath integrity. PMP22 influences axonal function and communicates signals that support myelin maintenance and regeneration. Disturbances in these pathways can lead to compromised nerve conduction and peripheral neuropathies.

Mutations or overexpression in PMP22 are connected to Charcot-Marie-Tooth disease type 1A and Hereditary Neuropathy with Liability to Pressure Palsies. These conditions reflect the critical role of PMP22 in nerve function where its interactions with proteins like Connexin32 become significant. Abnormalities in PMP22 can lead to demyelination resulting in nerve damage and the clinical manifestations associated with these neuropathies.
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Fundamental & clinical pharmacology 38:307-319 PubMed37857403

2023

Epothilone B loaded in acellular nerve allograft enhanced sciatic nerve regeneration in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Zhikal Omar Khudhur,Shang Ziyad Abdulqadir,Abdullah Faqiyazdin Ahmed Mzury,Abdulrahman Aziz Rasoul,Shukur Wasman Smail,Mohammad B Ghayour,Arash Abdolmaleki

International journal of molecular sciences 21: PubMed32033476

2020

A Role of Microtubules in Oligodendrocyte Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Yoon Lee,Eun-Mi Hur
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