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AB254457

EPZ0156666, PRMT5 inhibitor

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MW 383.4 Da, Purity >98%. Selective, potent (IC50 = 22nM, Ki =5 nM) inhibitor of arginine methyltransferase 5 (PRMT5). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases.
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Chemical Structure - EPZ0156666, PRMT5 inhibitor (AB254457)
  • Chemical Structure

Supplier Data

Chemical Structure - EPZ0156666, PRMT5 inhibitor (AB254457)

2D chemical structure image of ab254457, EPZ0156666, PRMT5 inhibitor

Key facts

CAS number

1616391-65-1

Purity

>98%

Form

Solid

form

Molecular weight

383.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>5</sub>N<sub>5</sub>O<sub>3</sub>

PubChem

90241673

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

(S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

Biological description

Selective, potent (IC50 = 22nM, Ki =5 nM) inhibitor of arginine methyltransferase 5 (PRMT5). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases.

Canonical smiles

C1CN(CC2=CC=CC=C21)CC(CNC(=O)C3=CC(=NC=N3)NC4COC4)O

Isomeric smiles

C1CN(CC2=CC=CC=C21)C[C@H](CNC(=O)C3=CC(=NC=N3)NC4COC4)O

InChi

InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4,7,13,16-17,26H,5-6,8-12H2,(H,21,27)(H,22,23,24)/t17-/m0/s1

InChiKey

ZKXZLIFRWWKZRY-KRWDZBQOSA-N

IUPAC Name

N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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