Erlotinib hydrochloride, EGFR tyrosine kinase inhibitor

Be the first to review this product! Submit a review

|

(6 Publications)

MW 429.9 Da, Purity >98%. Potent EGFR tyrosine kinase inhibitor (IC₅₀ = 2 nM). Decreases EGFR autophosphorylation in tumor cells. Potent inhibitor of mutant JAK2-V617F. Weaker inhibitor of ErbB-2 kinase (K_i = 1 μM) and ErbB-4 kinase (K_i = 1.5 μM). Clinically effective agent for non-small cell lung cancer (NSCLC).

View Alternative Names

94 kDa B raf protein, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, B Raf proto oncogene serine threonine protein kinase, B Raf proto oncogene, serine/threonine kinase, B raf 1, B-Raf proto-oncogene serine/threonine-protein kinase (p94), BRAF_HUMAN, C erb B2/neu protein, CD340, CD340 antigen, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, CerbB2, EGFR_HUMAN, ERBB, ERBB1, ERBB2_HUMAN, Epidermal growth factor receptor, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Erb b2 receptor tyrosine kinase 2, ErbB-2 proto-oncogene, Errp, FLJ95109, HER 2, HER 2/NEU, HER1, Herstatin, Human epidermal growth factor receptor 2, MGC126806, MGC138284, MLN 19, Metastatic lymph node gene 19 protein, Murine sarcoma viral (v-raf) oncogene homolog B1, Murine sarcoma viral v raf oncogene homolog B1, NEU, NEU proto oncogene, NGL, NISBD2, NS7, Neuro/glioblastoma derived oncogene homolog, Neuroblastoma/glioblastoma derived oncogene homolog, Oncogen BRAF, Oncogen ERBB, PIG61, Proto-oncogene B-Raf, Proto-oncogene Neu, Proto-oncogene c-ErbB-1, Proto-oncogene c-ErbB-2, Proto-oncogene c-Rmil, RAF, RAFB 1, RMIL, Receptor tyrosine-protein kinase ErbB-1, Receptor tyrosine-protein kinase erbB-2, SA7, Serine/threonine-protein kinase B-raf, Species antigen 7, TKR1, Tyrosine kinase-type cell surface receptor HER2, Urogastrone, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2, V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog), V erb b2 avian erythroblastic leukemia viral oncoprotein 2, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived-oncogene homolog, Wa5, cRmil, erb-b2 receptor tyrosine kinase 1, mENA, oncogene BRAF1, p185erbB2, p94, v raf murine sarcoma viral oncogene homolog B, v-Raf murine sarcoma viral oncogene homolog B1, v-erb-b Avian erythroblastic leukemia viral oncogen homolog, wa2