MW 367.4 Da, Purity >99%. H+ / K+-ATPase (proton pump) inhibitor (IC50 = 2.3 µM). *S*-enantiomer of omeprazole. Attenuates intestinal mucosal barrier damage and can promote healing of gastric lesions in rats. Also inhibits Cytochrome P450 2C19 (CYP2C9), CYP2C19 and CYP3A4 (Ki values are 81.5, 8.6 and 46.6 µM, respectively).
Images
Key facts
- CAS number
- 161796-78-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 367.4 Da
- Molecular formula
- C17H18N3NaO3S
- PubChem identifier
- 23674541
- Nature
- Synthetic
Recommended products
MW 367.4 Da, Purity >99%. H+ / K+-ATPase (proton pump) inhibitor (IC50 = 2.3 µM). *S*-enantiomer of omeprazole. Attenuates intestinal mucosal barrier damage and can promote healing of gastric lesions in rats. Also inhibits Cytochrome P450 2C19 (CYP2C9), CYP2C19 and CYP3A4 (Ki values are 81.5, 8.6 and 46.6 µM, respectively).
Key facts
- CAS number
- 161796-78-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 367.4 Da
- Molecular formula
- C17H18N3NaO3S
- PubChem identifier
- 23674541
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
Soluble in ethanol to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- sodium;5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
- Biological description
H+ / K+-ATPase (proton pump) inhibitor (IC50 = 2.3 µM). *S*-enantiomer of omeprazole. Attenuates intestinal mucosal barrier damage and can promote healing of gastric lesions in rats. Also inhibits Cytochrome P450 2C19 (CYP2C9), CYP2C19 and CYP3A4 (Ki values are 81.5, 8.6 and 46.6 µM, respectively).
- Canonical SMILES
- CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Na+]
- Isomeric SMILES
- CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Na+]
- InChI
- InChI=1S/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3;/q-1;+1/t24-;/m0./s1
- InChIKey
- RYXPMWYHEBGTRV-JIDHJSLPSA-N
- IUPAC name
- sodium;5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Chemical Structure - Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor (ab120500)
2D chemical structure image of ab120500, Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor
Functional Studies - Esomeprazole sodium, H+/ K+-ATPase (proton pump) inhibitor (ab120500)
MDA-MB-231 cells were incubated at 37°C for 6h with vehicle control (0 μM) and 100 μM of esomeprazole sodium (ab120500). Increased expression of aryl hydrocarbon receptor (ab2770) correlates with an increase in esomeprazole sodium concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 20 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 3% milk before being incubated with ab2770 at 2 μg/ml and Anti-beta Actin antibody [mAbcam 8226] - Loading Control ab8226 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-mouse antibody conjugated to HRP (Goat Anti-Mouse IgG H&L (HRP) preadsorbed ab97040) at 1/10000 dilution and visualised using ECL development solution.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com