MW 244.29 Da, Purity >98%. Agonist at GABAA receptors containing β3 subunits. Anaesthetic and amnesic properties. Achieve your results faster with highly validated, pure and trusted compounds.
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1,8-cineole 2-exo-monooxygenase, ALDOS, Albendazole monooxygenase, Albendazole sulfoxidase, Aldosterone synthase, Aldosterone-synthesizing enzyme, C11B2_HUMAN, CAE 2, CP33, CP34, CP3A4_HUMAN, CYP11B, CYP11B2, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, CYPXIB1, CYPXIB2, Cytochrome P 450c11, Cytochrome P-450Aldo, Cytochrome P-450C18, Cytochrome P450 11B1, mitochondrial, Cytochrome P450 11B2, Cytochrome P450 11B2, mitochondrial, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450, family 11, subfamily B, polypeptide 1, Cytochrome P450, subfamily XIB (steroid 11 beta hydroxylase), polypeptide 1, Cytochrome P450, subfamily XIB, polypeptide 1, Cytochrome P450-PCN1, Cytochrome p450 XIB1, ECA 2, ECA4, EIEE19, EJM, EJM5, FHI, GABA, GABA A receptor subunit alpha 2, GABA(A) receptor, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit gamma-2, GABA(A) receptor, alpha 1, GABA-A receptor, beta-2 polypeptide, GABR A2, GABRA 1, GABRA2 protein, GABRB2, GABRG 2, GBRA1_HUMAN, GBRA2_HUMAN, GBRB2_HUMAN, GBRG2_HUMAN, GEFSP 3, Gaba receptor alpha 1 polypeptide, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 2, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 2, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid receptor alpha 2 subunit, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric-acid receptor subunit beta-2, Glucocorticoid inducible P450, HLP, MGC126680, NF 25, Nifedipine oxidase, P 450C11, P-450Aldo, P-450C18, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, Quinine 3-monooxygenase, S11BH, Steroid 11 beta hydroxylase, Steroid 11 beta monooxygenase, Steroid 18-hydroxylase, Taurochenodeoxycholate 6-alpha-hydroxylase, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, mitochondrial
- FuncS
Unknown
Functional Studies - Etomidate, GABAA agonist (AB120311)
ab7977 staining BAX in RAW 264.7 cells treated with etomidate (ab120311), by ICC/IF. Increase in BAX expression correlates with increased concentration of etomidate, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120311 (etomidate) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
- Chemical Structure
Lab
Chemical Structure - Etomidate, GABAA agonist (AB120311)
2D chemical structure image of ab120311, Etomidate, GABAA agonist
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These GABA A receptors form pentameric complexes that modulate synaptic transmission. They are responsible for reducing neuronal excitability throughout the nervous system. They are essential for calming neural circuits and are modulated by several ligands and drugs like benzodiazepines. The modulation of these receptors can alter mood anxiety and epileptic states. In the adrenal cortex enzymes such as CYP11B1 also known as steroid 11β-hydroxylase and CYP11B2 also known as aldosterone synthase are involved in steroidogenesis converting cholesterol into glucocorticoids and mineralocorticoids important for stress response and electrolyte balance.
Pathways
CYP3A4 is prominent in the drug metabolism pathway and interacts closely with various drugs altering their efficacy and toxicity. The GABA A receptors on the other hand partake in the inhibitory neurotransmission pathway important for maintaining neural circuit balance. CYP3A4 shares pathways with proteins like CYP2D6 while GABA A receptors are interlinked with associated proteins like GABARAP (GABA receptor-associated protein) that aid in receptor trafficking and function.
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