Etomoxir (sodium salt), Carnitine palmitoyltransferase inhibitor

Key facts

CAS number

828934-41-4

Purity

>98%

Form

Solid

form

Molecular weight

320.74 Da

Molecular formula

C₁₅H₁₈ClNaO₄

PubChem

57345784

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM with warming

Biochemical name

(R)-(+)-Etomoxir sodium salt

Biological description

Irreverisble inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1). PPARα direct agonist. Used in fatty acid oxidation studies. Induces ROS production in T cells with concentrations larger than 5μM and prevents T cell differentiation. Complex I of electron transport chain inhibited at concentration 200μM.

Canonical smiles

C1C(O1)(CCCCCCOC2=CC=C(C=C2)Cl)C(=O)[O-].[Na+]

Isomeric smiles

C1[C@](O1)(CCCCCCOC2=CC=C(C=C2)Cl)C(=O)[O-].[Na+]

InChi

InChI=1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1

InChiKey

RPACBEVZENYWOL-XFULWGLBSA-M

IUPAC Name

sodium;(2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate