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AB120227

Etoposide, Topoisomerase II inhibitor

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(13 Publications)

MW 588.6 Da, Purity >98%. Topoisomerase II inhibitor. Anticancer agent. Achieve your results faster with highly validated, pure and trusted compounds.
1 Images
Chemical Structure - Etoposide, Topoisomerase II inhibitor (AB120227)
  • Chemical Structure

Lab

Chemical Structure - Etoposide, Topoisomerase II inhibitor (AB120227)

2D chemical structure image of ab120227, Etoposide, Topoisomerase II inhibitor

Key facts

CAS number

33419-42-0

Purity

>98%

Form

Solid

form

Molecular weight

588.6 Da

Molecular formula

C<sub>2</sub><sub>9</sub>H<sub>3</sub><sub>2</sub>O<sub>1</sub><sub>3</sub>

PubChem

36462

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Etoposide

Biological description

Topoisomerase II inhibitor. Anticancer agent.

Canonical smiles

CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

Isomeric smiles

C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O

InChi

InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChiKey

VJJPUSNTGOMMGY-MRVIYFEKSA-N

IUPAC Name

(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

Apoptosis : an international journal on programmed cell death 29:1145-1160 PubMed38684550

2024

ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP.

Applications

Unspecified application

Species

Unspecified reactive species

Ruqaia Abbas,Oliver Hartmann,Dorin Theodora Asiss,Rabab Abbas,Julia Kagan,Hyoung-Tae Kim,Moshe Oren,Markus Diefenbacher,Amir Orian,Sarit Larisch

Frontiers in veterinary science 10:1154987 PubMed37346276

2023

Influence of Rho/ROCK inhibitor Y-27632 on proliferation of equine mesenchymal stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Michaela Melzer,Janina Burk,Deborah J Guest,Jayesh Dudhia

Cell reports 40:111097 PubMed35858551

2022

Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Ridwan Islam,Juhi Mishra,Navatha Shree Polavaram,Sreyashi Bhattacharya,Zhengdong Hong,Sanika Bodas,Sunandini Sharma,Alyssa Bouska,Tyler Gilbreath,Ahmed M Said,Lynette M Smith,Benjamin A Teply,Michael H Muders,Surinder K Batra,Kaustubh Datta,Samikshan Dutta

Scientific reports 11:23221 PubMed34853379

2021

Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Federico A Moretti,Giuliana Giardino,Teresa C H Attenborough,Athina Soragia Gkazi,Ben K Margetts,Giancarlo la Marca,Lynette Fairbanks,Tessa Crompton,H Bobby Gaspar

Atherosclerosis 322:51-60 PubMed33706083

2021

Impact of myeloid RIPK1 gene deletion on atherogenesis in ApoE-deficient mice.

Applications

Unspecified application

Species

Unspecified reactive species

Isabelle Coornaert,Pauline Puylaert,Giullia Marcasolli,Mandy O J Grootaert,Peter Vandenabeele,Guido R Y De Meyer,Wim Martinet

Journal of leukocyte biology 110:343-356 PubMed33205451

2020

Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors.

Applications

Unspecified application

Species

Unspecified reactive species

Nizar Hijaze,Max Ledersnaider,Elina Simanovich,Sameer Kassem,Michal A Rahat

Communications biology 3:245 PubMed32427887

2020

Tau affects P53 function and cell fate during the DNA damage response.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Sola,Claudia Magrin,Giona Pedrioli,Sandra Pinton,Agnese Salvadè,Stéphanie Papin,Paolo Paganetti

Nature 580:647-652 PubMed32350463

2020

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.

Applications

Unspecified application

Species

Unspecified reactive species

Catherine R Lammert,Elizabeth L Frost,Calli E Bellinger,Ashley C Bolte,Celia A McKee,Mariah E Hurt,Matt J Paysour,Hannah E Ennerfelt,John R Lukens

Immunology letters 220:51-62 PubMed32032616

2020

Etoposide-mediated depletion of peripheral blood monocytes post s.aureus infection attenuates septic arthritis by modulating macrophage-derived factors responsible for inflammatory destruction.

Applications

Unspecified application

Species

Unspecified reactive species

Sahin Sultana,Biswadev Bishayi

Cell reports 30:1235-1245.e4 PubMed31995761

2020

The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks.

Applications

Unspecified application

Species

Unspecified reactive species

Qianghua Hu,Naeh Klages-Mundt,Rui Wang,Erica Lynn,Liton Kuma Saha,Huimin Zhang,Mrinal Srivastava,Xi Shen,Yanyan Tian,Hyeung Kim,Yin Ye,Tanya Paull,Shunichi Takeda,Junjie Chen,Lei Li
View all publications
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