EX-527, SIRT1 Inhibitor

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(14 Publications)

MW 248.71 Da, Purity >97%. Selective, cell-permeable SIRT1 Inhibitor. (IC₅₀= 98 nM, 19.6, 48.7 and > 100 μM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Shows no effect at other HDACs or SIRTs. Enhances p53 acetylation in response to DNA damaging agents.

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75SirT1, FLJ35621, FLJ37491, HST2, HST2, S. cerevisiae, homolog of, Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase, NAD dependent deacetylase sirtuin 3 mitochondrial, NAD dependent protein deacetylase sirtuin 1, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent protein deacetylase sirtuin-3, mitochondrial, OTTHUMP00000198111, OTTHUMP00000198112, Regulatory protein SIR2 homolog 1, Regulatory protein SIR2 homolog 2, Regulatory protein SIR2 homolog 3, SIR1_HUMAN, SIR2 L3, SIR2 like 1, SIR2, S. cerevisiae, homolog-loke 2, SIR2, S.cerevisiae, homolog-like 1, SIR2-like protein 1, SIR2-like protein 2, SIR2-like protein 3, SIR2ALPHA, SIR2L, SIR2L1, SIR2L2, SIR3_HUMAN, SIRT 2, SIRT2_HUMAN, Silencing information regulator 2 like, Silent information regulator 2, Silent mating type information regulation 2 S.cerevisiae homolog 3, Sir 2 like 3, Sir2 related protein type 2, SirtT1 75 kDa fragment, Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), Sirtuin 1, Sirtuin 2, Sirtuin 3, Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae), Sirtuin type 1, Sirtuin type 2, Sirtuin type 3, hSIR2, hSIRT 3, hSIRT1