(E,Z)-4-Hydroxytamoxifen (17197F0KYM), estrogen receptor modulator
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MW 387.5 Da, Purity >97%. Potent and selective estrogen receptor modulator. Mixture of (Z)-4-Hydroxytamoxifen (ab141943) and (E)-4-Hydroxytamoxifen (ab143637) isomers. Tamoxifen (ab120656) metabolite. Inhibits lipid peroxidation. Shows estrogenic and antiestrogenic effects in vivo. Orally active.
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Atherosclerosis, susceptibility to, included, Choline phosphatase 2, DKFZp686N23123, DKFZp781L1617, EC 3.1.4.4, ER, ER-alpha, ER-beta, ERR B2, ERR G2, ERR b, ERR beta-2, ERR gamma-2, ERR-beta, ERR2_HUMAN, ERR3_HUMAN, ERRgamma, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR L2, ESR1_HUMAN, ESR2_HUMAN, ESRA, ESRRG, ESTR B, Era, Erb, Erb2, Esrrb, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta, Estrogen receptor beta 4, Estrogen receptor related 2, Estrogen receptor-like 2, Estrogen receptor-related protein 3, Estrogen resistance, included, Estrogen-related receptor beta, Estrogen-related receptor gamma, Estrrb, FLJ16023, HDL cholesterol, augmented response of, to hormone replacement, included, KIAA0832, Myocardial infarction, susceptibility to, included, NR3A1, NR3A2, NR3B3, NR3C3, Nr3b2, Nuclear receptor ERRB2, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 2, Nuclear receptor subfamily 3 group B member 3, Nuclear receptor subfamily 3 group C member 3, OTTHUMP00000017718, OTTHUMP00000017719, Orphan nuclear receptor, PGR, PLD1C, PLD2_HUMAN, PR, PRA, PRB, PRGR_HUMAN, Phosphatidylcholine-hydrolyzing phospholipase D2, Phospholipase D2, Pldc, Progesterone receptor, Progestin receptor form A, Progestin receptor form B, RNESTROR, Steroid hormone receptor ERR 2, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b, hPLD 2, mPLD2, rPLD2
- Chemical Structure
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Chemical Structure - (E,Z)-4-Hydroxytamoxifen (17197F0KYM), estrogen receptor modulator (AB143638)
2D chemical structure image of ab143638, (E,Z)-4-Hydroxytamoxifen (17197F0KYM), estrogen receptor modulator
Properties and storage information
Shipped at conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These receptors and enzymes play significant roles in regulating cellular proliferation differentiation and survival. Estrogen receptors alpha and beta often form heterodimers or homodimers influencing gene expression in response to estrogen. Progesterone receptor activation helps modulate reproductive processes and neuroprotection. The esterogen-related receptors beta and gamma while orphan receptors play roles in energy metabolism and mitochondrial functions. PLD2 contributes to signal transduction and membrane trafficking.
Pathways
The progesterone and estrogen receptors are key components of the steroid hormone signaling pathway influencing cellular processes like development and metabolism. These receptors interact with other proteins like coactivators and corepressors to regulate transcriptional activity. On the other hand PLD2 is part of the phosphatidic acid signaling pathway involved in cellular signaling and membrane dynamics. Through these pathways the proteins ensure the regulation of various physiological processes including gene transcription and protein synthesis.
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