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AB144503

FAK Inhibitor 14, FAK autophosphorylation inhibitor

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(5 Publications)

MW 174.63 Da. Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC50 = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.
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Chemical Structure - FAK Inhibitor 14, FAK autophosphorylation inhibitor (AB144503)
  • Chemical Structure

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Chemical Structure - FAK Inhibitor 14, FAK autophosphorylation inhibitor (AB144503)

2D chemical structure image of ab144503, FAK Inhibitor 14, FAK autophosphorylation inhibitor

Key facts

CAS number

4506-66-5

Form

Solid

form

Molecular weight

174.63 Da

Molecular formula

C<sub>6</sub>H<sub>1</sub><sub>1</sub>ClN<sub>4</sub>

PubChem

381091

Nature

Synthetic

Biochemical name

1,4,5-Tetraaminobenzene tetrahydrochloride

Biological description

Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC50 = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.

Canonical smiles

C1=C(C(=CC(=C1N)N)N)N.Cl

InChi

InChI=1S/C6H10N4.ClH/c7-3-1-4(8)6(10)2-5(3)9;/h1-2H,7-10H2;1H

InChiKey

NZLYXIUDQUBQGU-UHFFFAOYSA-N

IUPAC Name

benzene-1,2,4,5-tetramine;hydrochloride

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Biochemicals

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SB 203580, p38 MAPK inhibitor

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Biochemicals

AB141406

PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant

Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (AB141406)

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Biochemicals

AB120225

Harmine, DYRK1A inhibitor

Chemical Structure - Harmine, DYRK1A inhibitor (AB120225)

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Biochemicals

AB141453

Puromycin dihydrochloride, Protein biosynthesis inhibitor

Chemical Structure - Puromycin dihydrochloride, Protein biosynthesis inhibitor (AB141453)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:19862 PubMed39191795

2024

Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis.

Applications

Unspecified application

Species

Unspecified reactive species

Paula Turkki,Iftekhar Chowdhury,Tiina Öhman,Latifeh Azizi,Markku Varjosalo,Vesa P Hytönen

Cancers 14: PubMed35884490

2022

Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zeinab Kosibaty,Odd Terje Brustugun,Inger Johanne Zwicky Eide,Georgios Tsakonas,Oscar Grundberg,Luigi De Petris,Marc McGowan,Per Hydbring,Simon Ekman

Stem cells international 2020:8857380 PubMed33204279

2020

Bionic Silk Fibroin Film Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells by Activating Focal Adhesion Kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Kang Lu,Xiaodie Chen,Hong Tang,Mei Zhou,Gang He,Zhisong Lu,Kanglai Tang

American journal of physiology. Renal physiology 319:F579-F591 PubMed32799673

2020

Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Noriyuki Yamashita,Tetsuro Kusaba,Tomohiro Nakata,Aya Tomita,Tomoharu Ida,Noriko Watanabe-Uehara,Kisho Ikeda,Takashi Kitani,Masahiro Uehara,Yuhei Kirita,Satoaki Matoba,Benjamin D Humphreys,Keiichi Tamagaki

Nature communications 9:4891 PubMed30459308

2018

Bimodal sensing of guidance cues in mechanically distinct microenvironments.

Applications

Unspecified application

Species

Unspecified reactive species

Erdem D Tabdanov,Vikram V Puram,Zaw Win,Ashab Alamgir,Patrick W Alford,Paolo P Provenzano
View all publications
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