MW 174.63 Da. Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC50 = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.
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- Cancers 14:2022Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZeinab Kosibaty,Odd Terje Brustugun,Inger Johanne Zwicky Eide,Georgios Tsakonas,Oscar Grundberg,Luigi De Petris,Marc McGowan,Per Hydbring,Simon EkmanPubMed 35884490
- Stem cells international 2020:88573802020Bionic Silk Fibroin Film Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells by Activating Focal Adhesion Kinase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKang Lu et. al.PubMed 33204279
- American journal of physiology. Renal physiology 319:F579-F5912020Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNoriyuki Yamashita,Tetsuro Kusaba,Tomohiro Nakata,Aya Tomita,Tomoharu Ida,Noriko Watanabe-Uehara,Kisho Ikeda,Takashi Kitani,Masahiro Uehara,Yuhei Kirita,Satoaki Matoba,Benjamin D Humphreys,Keiichi TamagakiPubMed 32799673
- Nature communications 9:48912018Bimodal sensing of guidance cues in mechanically distinct microenvironments.Applications:Unspecified applicationReactive species:Unspecified reactive speciesErdem D Tabdanov et. al.PubMed 30459308
Key facts
- CAS number
- 4506-66-5
- Form
- Solid
- Molecular weight
- 174.63 Da
- Molecular formula
- C6H11ClN4
- PubChem identifier
- 381091
- Nature
- Synthetic
Recommended products
MW 174.63 Da. Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC50 = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.
Key facts
- CAS number
- 4506-66-5
- Form
- Solid
- Molecular weight
- 174.63 Da
- Molecular formula
- C6H11ClN4
- PubChem identifier
- 381091
- Nature
- Synthetic
- Biochemical name
- 1,4,5-Tetraaminobenzene tetrahydrochloride
- Biological description
Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC50 = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.
- Canonical SMILES
- C1=C(C(=CC(=C1N)N)N)N.Cl
- InChI
- InChI=1S/C6H10N4.ClH/c7-3-1-4(8)6(10)2-5(3)9;/h1-2H,7-10H2;1H
- InChIKey
- NZLYXIUDQUBQGU-UHFFFAOYSA-N
- IUPAC name
- benzene-1,2,4,5-tetramine;hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - FAK Inhibitor 14, FAK autophosphorylation inhibitor (ab144503)
2D chemical structure image of ab144503, FAK Inhibitor 14, FAK autophosphorylation inhibitor
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