FCCP uncoupler, mitochondrial oxidative phosphorylation is with purity of > 99%.
- Cited in over 40 publications
- Soluble in DMSO to 100 mM
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41 Publications for All applications
- Biophysical reports 3:1001342023Thioflavin T indicates mitochondrial membrane potential in mammalian cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmily Skates,Hadrien Delattre,Zoe Schofield,Munehiro Asally,Orkun S SoyerPubMed 38026684
- Science advances 9:eade63082023-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAfitz Da Silva,Junio Dort,Zakaria Orfi,Xuefang Pan,Sjanie Huang,Ikhui Kho,Emilie Heckel,Giacomo Muscarnera,Patrick Piet van Vliet,Luisa Sturiale,Angela Messina,Donata Agata Romeo,Clara D M van Karnebeek,Xiao-Yan Wen,Aleksander Hinek,Thomas Molina,Gregor Andelfinger,Benjamin Ellezam,Yojiro Yamanaka,Hernando J Olivos,Carlos R Morales,Jean-Sébastien Joyal,Dirk J Lefeber,Domenico Garozzo,Nicolas A Dumont,Alexey V PshezhetskyPubMed 37390204
- Stem cells translational medicine 11:1151-11642022Autophagy Enhances Longevity of Induced Pluripotent Stem Cell-Derived Endothelium via mTOR-Independent ULK1 Kinase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKatherine E Hekman,Kyle M Koss,David Z Ivancic,Congcong He,Jason A WertheimPubMed 36173887
- Cell cycle (Georgetown, Tex.) 21:2206-22212022Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCecilie Katrin Kristiansen,Anbin Chen,Lena Elise Høyland,Mathias Ziegler,Gareth John Sullivan,Laurence A Bindoff,Kristina Xiao LiangPubMed 35815665
- eLife 11:2022Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRubens Sautchuk,Brianna H Kalicharan,Katherine Escalera-Rivera,Jennifer H Jonason,George A Porter,Hani A Awad,Roman A EliseevPubMed 35635445
- International journal of pharmaceutics 621:1217802022Interaction of surfactant coated PLGA nanoparticles with in vitro human brain-like endothelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElisa L J Moya,Sonia M Lombardo,Elodie Vandenhaute,Marc Schneider,Caroline Mysiorek,Akif E Türeli,Takashi Kanda,Fumitaka Shimizu,Yasuteru Sano,Nathalie Maubon,Fabien Gosselet,Nazende Günday-Türeli,Marie-Pierre DehouckPubMed 35504427
- Biomolecules 11:2021Butyrate and Metformin Affect Energy Metabolism Independently of the Metabolic Phenotype in the Tumor Therapy Model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFelix B Meyer,Christian Marx,Sonja B Spangel,René ThierbachPubMed 34944475
- Cell metabolism 33:2464-2483.e182021Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarcel Morgenstern,Christian D Peikert,Philipp Lübbert,Ida Suppanz,Cinzia Klemm,Oliver Alka,Conny Steiert,Nataliia Naumenko,Alexander Schendzielorz,Laura Melchionda,Wignand W D Mühlhäuser,Bettina Knapp,Jakob D Busch,Sebastian B Stiller,Stefan Dannenmaier,Caroline Lindau,Mariya Licheva,Christopher Eickhorst,Riccardo Galbusera,Ralf M Zerbes,Michael T Ryan,Claudine Kraft,Vera Kozjak-Pavlovic,Friedel Drepper,Sven Dennerlein,Silke Oeljeklaus,Nikolaus Pfanner,Nils Wiedemann,Bettina WarscheidPubMed 34800366
- Pharmaceutics 13:2021Miniaturization and Automation of a Human In Vitro Blood-Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery.Applications:Unspecified applicationReactive species:Unspecified reactive speciesElisa L J Moya,Elodie Vandenhaute,Eleonora Rizzi,Marie-Christine Boucau,Johan Hachani,Nathalie Maubon,Fabien Gosselet,Marie-Pierre DehouckPubMed 34208550
- Cancer & metabolism 9:212021High-resolution spatiotemporal pH and pO imaging in head and neck and oesophageal carcinoma cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexandra Blancke Soares,Robert Meier,Gregor Liebsch,Sabina Schwenk-Zieger,Martin E Kirmaier,Sebastian Theurich,Magdalena Widmann,Martin Canis,Olivier Gires,Frank HaubnerPubMed 33947450
Key facts
- CAS number
- 370-86-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 254.17 Da
- Molecular formula
- C10H5F3N4O
- PubChem identifier
- 3330
- Nature
- Synthetic
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FCCP uncoupler, mitochondrial oxidative phosphorylation is with purity of > 99%.
- Cited in over 40 publications
- Soluble in DMSO to 100 mM
Key facts
- CAS number
- 370-86-5
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 254.17 Da
- Molecular formula
- C10H5F3N4O
- PubChem identifier
- 3330
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Carbonyl cyanide p-trifluoromethoxyphenylhydrazone
- Canonical SMILES
- C1=CC(=CC=C1NN=C(C#N)C#N)OC(F)(F)F
- InChI
- InChI=1S/C10H5F3N4O/c11-10(12,13)18-9-3-1-7(2-4-9)16-17-8(5-14)6-15/h1-4,16H
- IUPAC name
- 2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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2 product images
Image from Chan G K Y, et al. Plos One, 8(5), e63583. Fig S4,; doi: 10.1371/journal.pone.0063583Cellular Activation - FCCP, mitochondrial oxidative phosphorylation uncoupler (ab120081)
HT29 cells were treated with the indicated compounds ((etoposide, 10 µM; gemcitabine 0.1 µM; paclitaxel 0.01 µM; PD901 1 µM, VX-680 0.2 µM) for 24 hours before analysis of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) using the Seahorse XF96 extracellular flux analyzer. Baseline rates (black) were determined at the indicated times before the addition of oligomycin (green) and then FCCP (red). Rate data are normalized to per-well cell number determined by post-analysis high-content imaging.
Chemical Structure - FCCP, mitochondrial oxidative phosphorylation uncoupler (ab120081)
2D chemical structure image of ab120081, FCCP, mitochondrial oxidative phosphorylation uncoupler
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