JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB147482

FCCP, mitochondrial oxidative phosphorylation uncoupler (DMSO solution)

Be the first to review this product! Submit a review

|

(0 Publication)

MW 386.7 Da. Potent mitochondrial oxidative phosphorylation uncoupler (IC50 = 20 nM). Disrupts ATP synthesis by transporting protons across mitochondrial inner membranes. Depolarises mitochondrial membrane potential.

Key facts

CAS number

566-97-2

Form

Liquid

form

Molecular weight

386.7 Da

Molecular formula

C<sub>2</sub><sub>7</sub>H<sub>4</sub><sub>6</sub>O

PubChem

330

Nature

Synthetic

Biochemical name

Cholest-8-en-3-ol

Biological description

Potent mitochondrial oxidative phosphorylation uncoupler (IC50 = 20 nM). Disrupts ATP synthesis by transporting protons across mitochondrial inner membranes. Depolarises mitochondrial membrane potential.

Canonical smiles

CC(C)CCCC(C)C1CCC2C1(CCC3=C2CCC4C3(CCC(C4)O)C)C

InChi

InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3

InChiKey

QETLKNDKQOXZRP-UHFFFAOYSA-N

IUPAC Name

10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,5,6,7,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

50 mM
style
left-column

Complementary Products

Assay Kits

AB113851

DCFDA / H2DCFDA - Cellular ROS Assay Kit

Functional Studies (Act) - DCFDA / H2DCFDA - Cellular ROS Assay Kit (AB113851)

  • 5
  • 11
Assay Kits

AB113850

JC-1 - Mitochondrial Membrane Potential Assay Kit

Functional Studies - JC-1 - Mitochondrial Membrane Potential Assay Kit (AB113850)

  • 4
  • 5
Assay Kits

AB219943

Mitochondrial Superoxide Assay Kit (Fluorometric)

Functional Studies - Mitochondrial Superoxide Assay Kit (Fluorometric) (AB219943)

  • 0
  • 0
Assay Kits

AB113852

TMRE-Mitochondrial Membrane Potential Assay Kit

Functional Studies - TMRE-Mitochondrial Membrane Potential Assay Kit (AB113852)

  • 5
  • 4
style
left-column

Product details

Supplied in DMSO (50 mM).
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

|

Refer to SDS for further information.

style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com