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MW 266.68 Da, Purity >99%. Selective, potent mGlu5 receptor antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM at rat and human recombinant mGlu5 receptors, respectively). Displays inverse agonist properties and blocks mGlu5 receptor basal activity (IC50 = 84 nM). Orally active, atypical anxiolytic.
Alternative names=GLUR, Smp_128940
- CAS number
57653-26-6
- Purity
> 99%
- Form
Solid
- Molecular weight
266.68 Da
- Molecular formula
C11H11ClN4O2
- PubChem identifier
162834
- Nature
Synthetic
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MW 266.68 Da, Purity >99%. Selective, potent mGlu5 receptor antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM at rat and human recombinant mGlu5 receptors, respectively). Displays inverse agonist properties and blocks mGlu5 receptor basal activity (IC50 = 84 nM). Orally active, atypical anxiolytic.
Alternative names=GLUR, Smp_128940
Key facts
- CAS number
57653-26-6
- Purity
> 99%
- Form
Solid
- Molecular weight
266.68 Da
- Molecular formula
C11H11ClN4O2
- PubChem identifier
162834
- Nature
Synthetic
- Biochemical name
CID 162834
- Biological description
Selective, potent mGlu5 receptor antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM at rat and human recombinant mGlu5 receptors, respectively). Displays inverse agonist properties and blocks mGlu5 receptor basal activity (IC50 = 84 nM). Orally active, atypical anxiolytic.
- Canonical SMILES
CN1CC(=O)N=C1NC(=O)NC2=CC(=CC=C2)Cl
- Isomeric SMILES
CN1CC(=O)N=C1NC(=O)NC2=CC(=CC=C2)Cl
- InChI
InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
- InChIKey
DWPQODZAOSWNHB-UHFFFAOYSA-N
- IUPAC name
1-(3-chlorophenyl)-3-(3-methyl-5-oxo-4H-imidazol-2-yl)urea
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
+4°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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