AB120832

Fenofibrate, PPAR-alpha agonist

Name: Fenofibrate, PPAR-alpha agonist (CAS 49562-28-9) | Abcam
Brand: Abcam Limited
SKU: AB120832
Price: 55 USD
Availability: InStock

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(5 Publications)

MW 360.84 g/mol, Purity >99%. Potent and selective PPAR-α agonist (EC₅₀ values are 18 and 30 μM at mouse and human receptors, respectively). Affinity is 10-fold less at PPAR-γ (EC₅₀ values are 250 and 300 μM at mouse and human receptors, respectively). Hypolipidemic agent.

1 Images

Chemical Structure - Fenofibrate, PPAR-alpha agonist (AB120832)

Chemical Structure

Lab

Chemical Structure - Fenofibrate, PPAR-alpha agonist (AB120832)

2D chemical structure image of ab120832, Fenofibrate, PPAR-alpha agonist

Key facts

CAS number

49562-28-9

Purity

>99%

Form

Solid

form

Molecular weight

360.84 g/mol

Molecular formula

C20H21ClO4

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biological description

Potent and selective PPAR-α agonist (EC₅₀ values are 18 and 30 μM at mouse and human receptors, respectively). Affinity is 10-fold less at PPAR-γ (EC₅₀ values are 250 and 300 μM at mouse and human receptors, respectively). Hypolipidemic agent.

IUPAC Name

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
Visit the Troubleshooting

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Science advances 10:eado5887 PubMed39454000

2024

Mitochondrial fatty acid oxidation drives senescence.

Applications

Unspecified application

Species

Unspecified reactive species

Shota Yamauchi,Yuki Sugiura,Junji Yamaguchi,Xiangyu Zhou,Satoshi Takenaka,Takeru Odawara,Shunsuke Fukaya,Takao Fujisawa,Isao Naguro,Yasuo Uchiyama,Akiko Takahashi,Hidenori Ichijo

Heliyon 10:e31923 PubMed38845919

2024

Comparative efficacy of sweated and non-sweated Bge. extracts on acute myocardial ischemia via regulating the PPARα/RXRα/NF-κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxiao Shan,Junying Li,Bangzhen Hong,Huihui Yin,Ziyi Lu,Guokai Wang,Nianjun Yu,Daiyin Peng,Lei Wang,Caiyun Zhang,Weidong Chen

Frontiers in pharmacology 13:1000254 PubMed36588740

2022

Fenofibrate suppresses corneal neovascularization by regulating lipid metabolism through PPARα signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tong Zhou,Ke Yan,Yuhan Zhang,Linfangzi Zhu,Yi Liao,Xiaoxiang Zheng,Yongxiong Chen,Xiaoxin Li,Zuguo Liu,Zhaoqiang Zhang

Nature metabolism 1:291-303 PubMed31032475

2019

TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Hirokazu Takahashi,Christiano R R Alves,Kristin I Stanford,Roeland J W Middelbeek, Pasquale Nigro,Rebecca E Ryan,Ruidan Xue,Masaji Sakaguchi,Matthew D Lynes,Kawai So,Joram D Mul,Min-Young Lee,Estelle Balan,Hui Pan,Jonathan M Dreyfuss,Michael F Hirshman,Mohamad Azhar,Jarna C Hannukainen,Pirjo Nuutila,Kari K Kalliokoski,Søren Nielsen,Bente K Pedersen,C Ronald Kahn,Yu-Hua Tseng,Laurie J Goodyear

Current molecular medicine 18:698-710 PubMed30734676

2019

Naoxintong Retards Atherosclerosis by Inhibiting Foam Cell Formation Through Activating Pparα Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zeng Wang,Huairui Shi,Huan Zhao,Zhen Dong,Buchang Zhao,Xinyu Weng,Rongle Liu,Xiao Li,Kai Hu,Yunzeng Zou,Aijun Sun,Junbo Ge

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Fenofibrate, PPAR-alpha agonist

Chemical Structure - Fenofibrate, PPAR-alpha agonist (AB120832)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

Nature

Solubility

Biological description

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (5)

Complementary Products

Secondary Antibodies

Biochemicals

Primary Antibodies

Primary Antibodies

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