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AB146169

Ferrostatin 1, erastin-induced ferroptosis inhibitor

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(4 Publications)

MW 262.35 g/mol. Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.
1 Images
Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (AB146169)
  • Chemical Structure

Lab

Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (AB146169)

2D chemical structure image of ab146169, Ferrostatin 1, erastin-induced ferroptosis inhibitor

Key facts

CAS number

347174-05-4

Form

Solid

form

Molecular weight

262.35 g/mol

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>2</sub><sub>2</sub>N<sub>2</sub>O<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in DMSO (up to 100 mg/ml)

Soluble in Ethanol (up to 100 mg/ml)

Biological description

Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.

Canonical smiles

O=C(OCC)C2CCC(NC1CCCCC1)C(N)C2

InChi

InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3

InChiKey

UJHBVMHOBZBWMX-UHFFFAOYSA-N

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Complementary Products

Biochemicals

AB209693

Erastin, ferroptosis activator

Chemical Structure - Erastin, ferroptosis activator (AB209693)

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Primary Antibodies

AB125066

Anti-Glutathione Peroxidase 4 antibody [EPNCIR144]

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutathione Peroxidase 4 antibody [EPNCIR144] (AB125066)

  • 5
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Assay Kits

AB118970

Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric)

Biochemical assay - Lipid Peroxidation (MDA) Assay Kit (Colorimetric/Fluorometric) (AB118970)

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  • 3
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Cell death and differentiation 32:1679-1690 PubMed40188196

2025

GCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Zixiang Chen,Kaifeng Niu,Mengge Li,Yuchun Deng,Ji Zhang,Di Wei,Jiaqi Wang,Yongliang Zhao

Redox biology 79:103479 PubMed39742570

2025

NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Kaifeng Niu,Zixiang Chen,Mengge Li,Guannan Ma,Yuchun Deng,Ji Zhang,Di Wei,Jiaqi Wang,Yongliang Zhao

Cell death & disease 13:662 PubMed35906211

2022

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiyuki Henning,Ursula Sarah Blind,Safa Larafa,Johann Matschke,Joachim Fandrey

Cell 171:628-641.e26 PubMed29053969

2017

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Applications

Unspecified application

Species

Unspecified reactive species

Sally E Wenzel,Yulia Y Tyurina,Jinming Zhao,Claudette M St Croix,Haider H Dar,Gaowei Mao,Vladimir A Tyurin,Tamil S Anthonymuthu,Alexandr A Kapralov,Andrew A Amoscato,Karolina Mikulska-Ruminska,Indira H Shrivastava,Elizabeth M Kenny,Qin Yang,Joel C Rosenbaum,Louis J Sparvero,David R Emlet,Xiaoyan Wen,Yoshinori Minami,Feng Qu,Simon C Watkins,Theodore R Holman,Andrew P VanDemark,John A Kellum,Ivet Bahar,Hülya Bayır,Valerian E Kagan
View all publications
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Product promise

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