MW 262.35 g/mol. Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.
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- Cell death & disease 13:6622022Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoshiyuki Henning,Ursula Sarah Blind,Safa Larafa,Johann Matschke,Joachim FandreyPubMed 35906211
- Cell 171:628-641.e262017PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSally E Wenzel,Yulia Y Tyurina,Jinming Zhao,Claudette M St Croix,Haider H Dar,Gaowei Mao,Vladimir A Tyurin,Tamil S Anthonymuthu,Alexandr A Kapralov,Andrew A Amoscato,Karolina Mikulska-Ruminska,Indira H Shrivastava,Elizabeth M Kenny,Qin Yang,Joel C Rosenbaum,Louis J Sparvero,David R Emlet,Xiaoyan Wen,Yoshinori Minami,Feng Qu,Simon C Watkins,Theodore R Holman,Andrew P VanDemark,John A Kellum,Ivet Bahar,Hülya Bayır,Valerian E KaganPubMed 29053969
Key facts
- CAS number
- 347174-05-4
- Form
- Solid
- Molecular weight
- 262.35 g/mol
- Molecular formula
- C15H22N2O2
- Nature
- Synthetic
Recommended products
MW 262.35 g/mol. Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.
Key facts
- CAS number
- 347174-05-4
- Form
- Solid
- Molecular weight
- 262.35 g/mol
- Molecular formula
- C15H22N2O2
- Nature
- Synthetic
- Solubility
Soluble in DMSO (up to 100 mg/ml).
Soluble in Ethanol (up to 100 mg/ml).
- Biological description
Potent, selective erastin-induced ferroptosis inhibitor (EC50 = 60 nM). Selectively inhibits Ras selective lethal compound-induced death. Blocks Artesunate (ab142829)-induced lipid peroxidation and cell death. Has no effect on CYP2E1 expression or cellular GSH level.
- Canonical SMILES
- O=C(OCC)C2CCC(NC1CCCCC1)C(N)C2
- InChI
- InChI=1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
- InChIKey
- UJHBVMHOBZBWMX-UHFFFAOYSA-N
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- The product can be stored for up to 12 months
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1 product image
Chemical Structure - Ferrostatin 1, erastin-induced ferroptosis inhibitor (ab146169)
2D chemical structure image of ab146169, Ferrostatin 1, erastin-induced ferroptosis inhibitor
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