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MW 358.5 Da, Purity >98%. Potent ERα agonist and ERβ agonist / antagonist (IC50 values are 33 and 181 nM for ERα and ERβ respectively). Increases calcium permeability in the lipid bilayer. Induces apoptosis. Shows selective cytotoxic effects to tumor cells. Shows chemopreventive and anticancer effects in vivo. .

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Images

Chemical Structure - Ferutinin, ERalpha agonist (AB144254), expandable thumbnail

Key facts

CAS number
41743-44-6
Purity
> 98%
Molecular weight
358.5 Da
Molecular formula
C22H30O4
PubChem identifier
354654
Nature
Synthetic

Target data

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MW 358.5 Da, Purity >98%. Potent ERα agonist and ERβ agonist / antagonist (IC50 values are 33 and 181 nM for ERα and ERβ respectively). Increases calcium permeability in the lipid bilayer. Induces apoptosis. Shows selective cytotoxic effects to tumor cells. Shows chemopreventive and anticancer effects in vivo. .

Key facts

Purity
> 98%
PubChem identifier
354654
Solubility

Soluble in DMSO.

Biochemical name
Ferutinine
Biological description

Potent ERα agonist and ERβ agonist / antagonist (IC50 values are 33 and 181 nM for ERα and ERβ respectively). Increases calcium permeability in the lipid bilayer. Induces apoptosis. Shows selective cytotoxic effects to tumor cells. Shows chemopreventive and anticancer effects in vivo.

Canonical SMILES
CC1=CCC2(CCC(C2C(C1)OC(=O)C3=CC=C(C=C3)O)(C(C)C)O)C
Isomeric SMILES
CC1=CC[C@]2(CC[C@]([C@@H]2[C@H](C1)OC(=O)C3=CC=C(C=C3)O)(C(C)C)O)C
InChI
InChI=1S/C22H30O4/c1-14(2)22(25)12-11-21(4)10-9-15(3)13-18(19(21)22)26-20(24)16-5-7-17(23)8-6-16/h5-9,14,18-19,23,25H,10-13H2,1-4H3/t18-,19+,21-,22+/m0/s1
InChIKey
CYSHNJQMYORNJI-YUVXSKOASA-N
IUPAC name
[(3R,3aS,4S,8aR)-3-hydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl] 4-hydroxybenzoate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive, Store in the dark

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1 product image

  • Chemical Structure - Ferutinin, ERalpha agonist (ab144254), expandable thumbnail

    Chemical Structure - Ferutinin, ERalpha agonist (ab144254)

    2D chemical structure image of ab144254, Ferutinin, ERalpha agonist

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Product protocols

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