FFN511, Fluorescent substrate for VMAT2

Key facts

CAS number

1004548-96-2

Purity

>98%

Form

Solid

form

Molecular weight

284.35 Da

Molecular formula

C₁₇H₂₀N₂O₂

PubChem

23725121

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

False Fluorescent Neurotransmitter 511, FFN-511

Biological description

First novel fluorescent false neurotransmitter. Enables optical imaging of presynaptic terminal activity.
Inhibits 5-HT binding to VMAT2 (IC₅₀ = 1 μM (comparable to dopamine itself)). Released via exocytosis in the striatum in mouse acute slice preparation. Labels dopamine and other presynaptic terminals in the striatum.
Compatible with GFP tags and other optical probes. Sufficiently bright, photostable and suitable for two-photon fluorescence microscopy.
View the technique online

For highly selective labelling of dopaminergic presynaptic termainals FFN102 (ab120866) is recommended.

Canonical smiles

C1CC2=CC3=C(C4=C2N(C1)CCC4)OC(=O)C=C3CCN

InChi

InChI=1S/C17H20N2O2/c18-6-5-11-10-15(20)21-17-13-4-2-8-19-7-1-3-12(16(13)19)9-14(11)17/h9-10H,1-8,18H2

InChiKey

SKTIZSRPCXRDHX-UHFFFAOYSA-N

IUPAC Name

6-(2-aminoethyl)-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2(7),5,8-tetraen-4-one