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MW 361.2 Da, Purity >98%. Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. Suppresses proliferation of cancer cells in vitro. Antitumor agent.

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Images

Chemical Structure - FH-535, Wnt/beta-cantenin inhibitor (AB144594), expandable thumbnail

Publications

  • PloS one 7:e444182012
    FH535 inhibited migration and growth of breast cancer cells.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    Joji Iida et. al.
    PubMed 22984505
  • International journal of toxicology 31:380-92012
    FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling.
    Applications:
    Unspecified application
    Reactive species:
    Unspecified reactive species
    William W Polk
    PubMed 22713211

Key facts

CAS number

108409-83-2

Purity

> 98%

Form

Solid

Molecular weight

361.2 Da

Molecular formula

C13H10Cl2N2O4S

PubChem identifier

3463933

Nature

Synthetic

Target data

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MW 361.2 Da, Purity >98%. Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. Suppresses proliferation of cancer cells in vitro. Antitumor agent.

Key facts

Purity

> 98%

PubChem identifier

3463933

Solubility

Soluble in DMSO to 75 mM.

Biochemical name

2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide

Biological description

Wnt/β-cantenin inhibitor and PPARγ and PPARδ antagonist. Suppresses proliferation of cancer cells in vitro. Antitumor agent.

Canonical SMILES

CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl

InChI

InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3

InChIKey

AXNUEXXEQGQWPA-UHFFFAOYSA-N

IUPAC name

2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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Terms & Conditions.

1 product image

  • Chemical Structure - FH-535, Wnt/beta-cantenin inhibitor (ab144594), expandable thumbnail

    Chemical Structure - FH-535, Wnt/beta-cantenin inhibitor (ab144594)

    2D chemical structure image of ab144594, FH-535, Wnt/beta-cantenin inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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