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AB285397

FITC-DEVD-FMK

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MW 923.91 g/mol, Purity >98%. A fluorescein isothiocyanate (FITC) conjugate of the cell-permeable caspase inhibitor D(OMe)E(OMe)VD(OMe)-FMK that acts as an in situ marker for detection of caspase-3 in living cells. FITC-D(OMe)E(OMe)VD(OMe)-FMK is nontoxic, and irreversibly binds to activated caspase-3 in apoptotic cells. The bound marker is localized by fluorescence detection.

Key facts

Purity

>98%

Form

Liquid

form

Molecular weight

923.91 g/mol

Molecular formula

C<sub>4</sub><sub>3</sub>H<sub>4</sub><sub>6</sub>FN<sub>5</sub>O<sub>1</sub><sub>5</sub>S

Nature

Synthetic

Biological description

A fluorescein isothiocyanate (FITC) conjugate of the cell-permeable caspase inhibitor D(OMe)E(OMe)VD(OMe)-FMK that acts as an in situ marker for detection of caspase-3 in living cells. FITC-D(OMe)E(OMe)VD(OMe)-FMK is nontoxic, and irreversibly binds to activated caspase-3 in apoptotic cells. The bound marker is localized by fluorescence detection

Isomeric smiles

O=C(OC)CC[C@H](NC([C@@H](N/C(S)=N/C1=CC=C(C2(C3=CC=C(O)C=C3OC4=C2C=CC(O)=C4)OC5=O)C5=C1)CC(OC)=O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O

InChi

InChI=1S/C43H46FN5O15S/c1-20(2)37(40(58)47-29(31(52)19-44)17-35(54)61-4)49-38(56)28(12-13-34(53)60-3)46-39(57)30(18-36(55)62-5)48-42(65)45-21-6-9-25-24(14-21)41(59)64-43(25)26-10-7-22(50)15-32(26)63-33-16-23(51)8-11-27(33)43/h6-11,14-16,20,28-30,37,50-51H,12-13,17-19H2,1-5H3,(H,46,57)(H,47,58)(H,49,56)(H2,45,48,65)/t28-,29-,30-,37-/m0/s1

InChiKey

GRXLYHYCYCURGM-OWBZZYPYSA-N

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Product details

A 0.6 mM solution in DMSO.

Protect from air and moisture.

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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this is air sensitive and impurities can occur as a result of air oxidation
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Product protocols

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