MW 438.5 Da. Notch signaling inhibitor (EC50 of 2.3 μM, kinase assay). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets. Inhibits Notch signaling in vivo. .
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- Journal of experimental & clinical cancer research : CR 40:3252021M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKai Li,Zi-Yang Peng,Shan Gao,Qing-Shi Wang,Rui Wang,Xiang Li,Guo-Dong Xiao,Jing Zhang,Hong Ren,Shou-Ching Tang,Xin SunPubMed 34656164
Key facts
- CAS number
- 313967-18-9
- Form
- Solid
- Molecular weight
- 438.5 Da
- Molecular formula
- C25H30N2O5
- PubChem identifier
- 3103157
- Nature
- Synthetic
Target data
Recommended products
MW 438.5 Da. Notch signaling inhibitor (EC50 of 2.3 μM, kinase assay). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets. Inhibits Notch signaling in vivo. .
Key facts
- CAS number
- 313967-18-9
- Form
- Solid
- Molecular weight
- 438.5 Da
- Molecular formula
- C25H30N2O5
- PubChem identifier
- 3103157
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 10 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
- Biological description
Notch signaling inhibitor (EC50 of 2.3 μM, kinase assay). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets. Inhibits Notch signaling in vivo.
- Canonical SMILES
- CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4
- InChI
- InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
- InChIKey
- SWWVFYHSSOWZMF-UHFFFAOYSA-N
- IUPAC name
- cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - FLI-06, Notch signaling inhibitor (ab146170)
2D chemical structure image of ab146170, FLI-06, Notch signaling inhibitor
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