JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB146170

FLI-06, Notch signaling inhibitor

Be the first to review this product! Submit a review

|

(1 Publication)

MW 438.5 Da. Notch signaling inhibitor (EC50 of 2.3 μM, kinase assay). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets. Inhibits Notch signaling in vivo. .
1 Images
Chemical Structure - FLI-06, Notch signaling inhibitor (AB146170)
  • Chemical Structure

Lab

Chemical Structure - FLI-06, Notch signaling inhibitor (AB146170)

2D chemical structure image of ab146170, FLI-06, Notch signaling inhibitor

Key facts

CAS number

313967-18-9

Form

Solid

form

Molecular weight

438.5 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>3</sub><sub>0</sub>N<sub>2</sub>O<sub>5</sub>

PubChem

3103157

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 100 mM

Biochemical name

Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Biological description

Notch signaling inhibitor (EC50 of 2.3 μM, kinase assay). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets. Inhibits Notch signaling in vivo.

Canonical smiles

CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4

InChi

InChI=1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3

InChiKey

SWWVFYHSSOWZMF-UHFFFAOYSA-N

IUPAC Name

cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,6,8-tetrahydroquinoline-3-carboxylate

style
left-column

Complementary Products

Biochemicals

AB282446

IMR-1

  • 0
  • 0
Primary Antibodies

AB52627

Anti-Notch1 antibody [EP1238Y]

RabMAb|Recombinant|KO Validated|20ul selling size|Advanced Validation

Western blot - Anti-Notch1 antibody [EP1238Y] (AB52627)

  • 5
  • 18
Biochemicals

AB142216

C59, Wnt Antagonist, Wnt signaling pathway inhibitor

Chemical Structure - C59, Wnt Antagonist, Wnt signaling pathway inhibitor (AB142216)

  • 0
  • 0
Proteins & Peptides

AB7403

Streptavidin (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Streptavidin (HRP) (AB7403)

  • 5
  • 7
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 40:325 PubMed34656164

2021

M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Li,Zi-Yang Peng,Shan Gao,Qing-Shi Wang,Rui Wang,Xiang Li,Guo-Dong Xiao,Jing Zhang,Hong Ren,Shou-Ching Tang,Xin Sun
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com