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MW 281.23 Da, Purity >98%. Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. Alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.

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Images

Chemical Structure - Flufenamic acid, COX inhibitor (AB120354), expandable thumbnail
  • Functional Studies - Flufenamic acid, COX inhibitor (AB120354), expandable thumbnail

Publications

Key facts

CAS number
530-78-9
Purity
> 98%
Form
Solid
Molecular weight
281.23 Da
Molecular formula
C14H10F3NO2
PubChem identifier
3371
Nature
Synthetic

Target data

Alternative names

17-beta-HSD 5, 17-beta-hydroxysteroid dehydrogenase type 5, 2-dihydrobenzene-1, 2-diol dehydrogenase, 20 alpha (3 alpha) hydroxysteroid dehydrogenase, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 2ALPHAHSD, 3 alpha hydroxysteroid dehydrogenase type II, 3 alpha hydroxysteroid dehydrogenase type III, 3-alpha-HSD type 2, 3-alpha-HSD type II, 3-alpha-HSD type II, brain, 3-alpha-HSD3, 3-alpha-hydroxysteroid dehydrogenase type 2, 84 kDa myeloperoxidase, 89 kDa myeloperoxidase, ADR, AI838772, AK1C1_HUMAN, AK1C2_HUMAN, AK1C3_HUMAN, AKR1B 1, AKR1C pseudo, AKR1C1, AKR1C2, ALDR_HUMAN, ALR2, AR, ARNT-interacting protein, ATTR, AW493413, Akr1c18, Aldehyde reductase, Aldehyde reductase 1, Aldo-keto reductase family 1 member B1, Aldo-keto reductase family 1 member C1, Aldo-keto reductase family 1 member C2, Aldo-keto reductase family 1 member C3, Aldo-keto reductase family, 1 member 1, Aldose reductase, Amyloid polyneuropathy, Amyloidosis I, Antigen NY-CO-13, BABP, BCC7, BXR, Basic-helix-loop-helix-PAS protein MOP1, Bile acid binding protein, C9, CTS, CTS1, Carpal tunnel syndrome 1, Cellular tumor antigen p53, Chlordecone reductase, Chlordecone reductase homolog, Chlordecone reductase homolog HAKRC, Chlordecone reductase homolog HAKRD, Chlordecone reductase homolog HAKRb, Class E basic helix-loop-helix protein 78, Cyclooxygenase, Cyclooxygenase 2b, Cyclooxygenase 3, included, Cyclooxygenase-1, Cyclooxygenase-2, DD, DD-2, DD-3, DD/BABP, DD1, DD1/DD2, DDH, DDH 2, DDH1, DDX, Dihydrodiol dehydrogenase 1, Dihydrodiol dehydrogenase 1/2, Dihydrodiol dehydrogenase 2, Dihydrodiol dehydrogenase 3, Dihydrodiol dehydrogenase X, Dihydrodiol dehydrogenase type I, Dihydrodiol dehydrogenase, type 1, Dihydrodiol dehydrogenase/bile acid-binding protein, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, EC 1.11.1.7, EC 1.14.99.1, EC1.11.2.2, Epididymis luminal protein 111, FLJ11090, FLJ53800, FLJ92943, GCCR, GCRST, GCR_HUMAN, GR, GRIPGHS, Glucocorticoid receptor, Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase, Glucocorticoid-regulated inflammatory cyclooxygenase, Grl1, H37, HA1753, HAKRB, HAKRC, HAKRD, HAKRe, HBAB, HD 7, HD 7B, HD 9, HDAC, HDAC 7B, HDAC 9B, HDAC 9FL, HDAC9_HUMAN, HDRP, HEL111, HIF-1, HIF-1-alpha, HIF-alpha, HIF1A_HUMAN, HSD17B5, Hepatic dihydrodiol dehydrogenase, High-affinity hepatic bile acid-binding protein, Histone deacetylase 4/5 related protein, Histone deacetylase 7, Histone deacetylase 7B, Histone deacetylase 9, Histone deacetylase 9A, Histone deacetylase-related protein, HsT2651, Hypoxia inducible factor 1 alpha isoform I.3, Hypoxia inducible factor 1 alpha subunit, Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor, Hypoxia inducible factor 1, alpha subunit (basic helix loop helix transcription factor), Hypoxia-inducible factor 1-alpha, Indanol dehydrogenase, KIAA0119, KIAA0744, LFS1, Lii5 2 CTCL tumor antigen, Low Km aldose reductase, MBAB, MCDR 2, MEF2 interacting transcription repressor protein, MEF2-interacting transcription repressor MITR, MGC104252, MGC112732, MGC1804, MGC8954, MITR, MOP 1, MPO, Macrophage activation-associated marker protein P71/73, Member of PAS protein 1, Member of PAS superfamily 1, Member of the PAS Superfamily 1, Mutant tumor protein 53, Myeloperoxidase, Myeloperoxidase heavy chain, Myeloperoxidase light chain, NR1I2_HUMAN, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 3 group C member 1, ONR 1, OTTHUMP00000033524, OTTHUMP00000044759, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, P53_HUMAN, PALB, PAR, PAR q, PAS domain-containing protein 8, PASD 8, PCOX1, PERM_HUMAN, PES-2, PGFS, PGG/HS, PGH synthase 1, PGH synthase 2, PGH1_HUMAN, PGH2_HUMAN, PGHS-1, PGHS-2, PHS 1, PHS 2, PHS II, PRR, PTGHS, PTGS1, PTGS2, Partial COX1 proteins, included, Phosphoprotein p53, Prealbumin, Prealbumin Thyroxine-binding, Prealbumin amyloidosis type I, Pregnane X receptor, Prostaglandin F synthase, Prostaglandin G/H synthase, Prostaglandin G/H synthase 1, Prostaglandin G/H synthase 2, Prostaglandin G/H synthase 2 precursor, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 1, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 1, Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin-endoperoxide synthase 2, Pseudo chlordecone reductase, RP24-311F12.2, SCAN1, SRXY8, SXR, Senile systemic amyloidosis, Steroid and xenobiotic receptor, TBPA, TIS10, TIS10 protein, TRP53, TTHY_HUMAN, TTR, TTR protein, TYDP, TYDP1_HUMAN, Testosterone 17-beta-dehydrogenase 5, Thyroxine binding prealbumin, Tp53, Trans-1, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Transformation related protein 53, Transthyretin, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Type II 3 alpha hydroxysteroid dehydrogenase, Type II dihydrodiol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase, Type IIb 3 alpha hydroxysteroid dehydrogenase, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, aldo-keto reductase C, aldo-keto reductase family 1, member B1 (aldose reductase), aldr 1, bHLHe78, dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, dihydrodiol dehydrogenase isoform DD1, fj02a10, fj80f04, glucocorticoid nuclear receptor variant 1, hCox 2, hifla, hluPGFS, mpx, myeloid-specific peroxidase, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), p53 tumor suppressor, pregnane X nuclear receptor variant 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), ptgs2a, tumor antigen p55, unp1239, wu:fj02a10, wu:fj80f04

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MW 281.23 Da, Purity >98%. Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. Alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.

Key facts

Purity
> 98%
PubChem identifier
3371
Solubility

Soluble in DMSO to 100 mM.

Soluble in ethanol to 100 mM.

Biochemical name
Flufenamic acid
Biological description

Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. Alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.

Canonical SMILES
C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F
InChI
InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
InChIKey
LPEPZBJOKDYZAD-UHFFFAOYSA-N
IUPAC name
2-[3-(trifluoromethyl)anilino]benzoic acid

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - Flufenamic acid, COX inhibitor (ab120354), expandable thumbnail

    Chemical Structure - Flufenamic acid, COX inhibitor (ab120354)

    2D chemical structure image of ab120354, Flufenamic acid, COX inhibitor

  • Functional Studies - Flufenamic acid, COX inhibitor (ab120354), expandable thumbnail

    Functional Studies - Flufenamic acid, COX inhibitor (ab120354)

    ab51110 staining AMPKα 1 + AMPKα 2 (phosphoT172) in HeLa cells treated with flufenamic acid (ab120354), by ICC/IF. Increase in AMPKα 1 + AMPKα 2 (phosphoT172) nuclear expression correlates with increased concentration of flufenamic acid, as described in literature.
    The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120354 (flufenamic acid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab51110 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody.

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