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AB120354

Flufenamic acid, COX inhibitor

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(2 Publications)

MW 281.23 Da, Purity >98%. Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. Alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.
2 Images
Functional Studies - Flufenamic acid, COX inhibitor (AB120354)
  • FuncS

Unknown

Functional Studies - Flufenamic acid, COX inhibitor (AB120354)

ab51110 staining AMPKα 1 + AMPKα 2 (phosphoT172) in HeLa cells treated with flufenamic acid (ab120354), by ICC/IF. Increase in AMPKα 1 + AMPKα 2 (phosphoT172) nuclear expression correlates with increased concentration of flufenamic acid, as described in literature.
The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120354 (flufenamic acid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab51110 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Chemical Structure - Flufenamic acid, COX inhibitor (AB120354)
  • Chemical Structure

Lab

Chemical Structure - Flufenamic acid, COX inhibitor (AB120354)

2D chemical structure image of ab120354, Flufenamic acid, COX inhibitor

Key facts

CAS number

530-78-9

Purity

>98%

Form

Solid

form

Molecular weight

281.23 Da

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>0</sub>F<sub>3</sub>NO<sub>2</sub>

PubChem

3371

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biochemical name

Flufenamic acid

Biological description

Non-steroidal anti-inflammatory. Potently inhibits human transthyretin amyloid fibril formation. Alters ion fluxes through the plasma membrane. Potent non-specific blocker of cation and anion channels, commonly used to block currents through TRP channels and receptor-operated channels.

Canonical smiles

C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F

InChi

InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)

InChiKey

LPEPZBJOKDYZAD-UHFFFAOYSA-N

IUPAC Name

2-[3-(trifluoromethyl)anilino]benzoic acid

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Complementary Products

Biochemicals

AB145522

TPCA 1, IkappaB kinase inhibitor

Chemical Structure - TPCA 1, IkappaB kinase inhibitor (AB145522)

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Biochemicals

AB144824

JSH 23, NFkappaB transcriptional activity inhibitor

Chemical Structure - JSH 23, NFkappaB transcriptional activity inhibitor (AB144824)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Biochemicals

AB120297

Phorbol 12-myristate 13-acetate (PMA), PKC activator

Chemical Structure - Phorbol 12-myristate 13-acetate (PMA), PKC activator (AB120297)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Investigative ophthalmology & visual science 62:28 PubMed34427623

2021

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shangru Sui,Hongxia Yu,Xiangji Wang,Wenyan Wang,Xuejiao Yang,Xiaojing Pan,Qingjun Zhou,Chen Xin,Rong Du,Shen Wu,Jingxue Zhang,Qilong Cao,Ningli Wang,Markus H Kuehn,Wei Zhu

Journal of diabetes research 2016:7262680 PubMed26788521

2016

Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas.

Applications

Unspecified application

Species

Unspecified reactive species

J Matthew Rhett,Hongjun Wang,Heather Bainbridge,Lili Song,Michael J Yost
View all publications
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