AB145254

Fluo-3 AM, Fluorescent calcium Indicator

Name: Fluo-3 AM, Fluorescent calcium Indicator (CAS 121714-22-5) | Abcam
Brand: Abcam Limited
SKU: AB145254
Price: 430 USD
Availability: InStock

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(11 Publications)

MW 1129.85 g/mol, Purity >95%. Cell-permeable acetoxymethyl (AM) ester of the fluorescent calcium indicator Fluo-3. Commonly used in cell-based experiments to detect changes in intracellular calcium levels. Practically nonfluorescent until it is hydrolyzed intracellularly to Fluo-3 and in the presence of Ca²⁺.

1 Images

Chemical Structure - Fluo-3 AM, Fluorescent calcium Indicator (AB145254)

Chemical Structure

Lab

Chemical Structure - Fluo-3 AM, Fluorescent calcium Indicator (AB145254)

2D chemical structure image of ab145254, Fluo-3 AM, Fluorescent calcium Indicator

Key facts

CAS number

121714-22-5

Purity

>95%

Form

Solid

form

Molecular weight

1129.85 g/mol

Molecular formula

C51H50Cl2N2O23

Nature

Synthetic

Solubility

Soluble in DMSO

Biological description

Cell-permeable acetoxymethyl (AM) ester of the fluorescent calcium indicator Fluo-3. Commonly used in cell-based experiments to detect changes in intracellular calcium levels. Practically nonfluorescent until it is hydrolyzed intracellularly to Fluo-3 and in the presence of Ca²⁺.

InChi

InChI=1S/C51H50Cl2N2O23/c1-28-7-9-39(54(19-47(62)74-24-69-30(3)57)20-48(63)75-25-70-31(4)58)45(13-28)66-11-12-67-46-14-34(8-10-40(46)55(21-49(64)76-26-71-32(5)59)22-50(65)77-27-72-33(6)60)51-35-15-37(52)41(61)17-42(35)78-43-18-44(38(53)16-36(43)51)73-23-68-29(2)56/h7-10,13-18H,11-12,19-27H2,1-6H3

InChiKey

PTPUOMXKXCCSEN-UHFFFAOYSA-N

Excitation/Emission

Ex: 506nm, Em: 526nm

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Biological trace element research : PubMed40580239

2025

Boric Acid Diminishes Sciatic Nerve Injury-Induced Apoptosis, Oxidative Stress, and Pain via The Block of TRPV1 Channel in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Kemal Ertilav,Mustafa Nazıroğlu

Bioactive materials 50:344-363 PubMed40297641

2025

Multifunctional piezoelectric hydrogels under ultrasound stimulation boost chondrogenesis by recruiting autologous stem cells and activating the Ca/CaM/CaN signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Bao Liu,Xu Liu,Xiao-Fei Li,Liang Qiao,Hao-Liang Wang,Yue-Fu Dong,Feng Zhang,Yang Liu,Hao-Yang Liu,Ming-Liang Ji,Lan Li,Qing Jiang,Jun Lu

Molecular neurobiology 61:7269-7286 PubMed38976129

2024

Resveratrol Modulates Diabetes-Induced Neuropathic Pain, Apoptosis, and Oxidative Neurotoxicity in Mice Through TRPV4 Channel Inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Haci Ömer Osmanlıoğlu,Mustafa Nazıroğlu

International journal of biological sciences 20:2658-2685 PubMed38725851

2024

Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Yuelin Xiao,Yiwang Zhang,Kaiduan Xie,Xiaoli Huang,Xianzhi Liu,Jinni Luo,Siwei Tan

Clinical and translational medicine 14:e1653 PubMed38616702

2024

Mitochondrial dysfunction induced by HIF-1α under hypoxia contributes to the development of gastric mucosal lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Yuelin Xiao,Xianzhi Liu,Kaiduan Xie,Jiajie Luo,Yiwang Zhang,Xiaoli Huang,Jinni Luo,Siwei Tan

Aging 13:9542-9565 PubMed33714957

2021

Gastrodin ameliorates learning and memory impairment in rats with vascular dementia by promoting autophagy flux via inhibition of the Ca/CaMKII signal pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Ting Chen,Xue Zhou,Yi-Ni Xu,Yue Li,Xiao-Ying Wu,Quan Xiang,Ling-Yun Fu,Xiao-Xia Hu,Ling Tao,Xiang-Chun Shen

Clinical science (London, England : 1979) 135:793-810 PubMed33625485

2021

Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Ziwei Fu,Fei Wang,Xiyang Liu,Jiajia Hu,Jiahui Su,Xiaohan Lu,Aihua Lu,Jae Min Cho,J David Symons,Chang-Jiang Zou,Tianxin Yang

Oxidative medicine and cellular longevity 2020:7386239 PubMed33488931

2020

Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoqing Chi,Xiaodan Ma,Zoushuyi Li,Yong Zhang,Yong Wang,Lijia Yuan,Ye Wu,Wei Xu,Songhua Hu

Nature communications 11:1822 PubMed32286278

2020

Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion.

Applications

Unspecified application

Species

Unspecified reactive species

Fangfang Zhang,Dongshen Ma,Wanli Zhao,Danwei Wang,Tingsheng Liu,Yuhong Liu,Yue Yang,Yue Liu,Jinming Mu,Bingbing Li,Yanfeng Zhang,Yi Pan,Changying Guo,Hong Du,Ling Li,Xianghui Fu,Zhengyu Cao,Liang Jin

Molecular medicine reports 20:1093-1102 PubMed31173208

2019

Calcium‑sensing receptor promotes high glucose‑induced myocardial fibrosis via upregulation of the TGF‑β1/Smads pathway in cardiac fibroblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Yuan,Yuqi Fan,Yuehong Wang,Tielei Gao,Yiying Shao,Bingbing Zhao,Hongzhu Li,Changqing Xu,Can Wei

View all publications

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Fluo-3 AM, Fluorescent calcium Indicator

Chemical Structure - Fluo-3 AM, Fluorescent calcium Indicator (AB145254)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

Nature

Solubility

Biological description

InChi

InChiKey

Excitation/Emission

Properties and storage information

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (11)

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Biochemicals

Reagents, Controls & Accessories

Biochemicals

Secondary Antibodies

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