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AB120077

Fluoxetine hydrochloride, 5-HT reuptake inhibitor

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(6 Publications)

MW 345.8 Da, Purity >99%. Potent, selective 5-HT reuptake inhibitor. Antidepressant in vivo. Binds to rat and human 5-HT transporters with Ki values of 2 and 0.9-20 nM, respectively. Shows around 150-900-fold selectivity over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic and muscarinic receptors.
2 Images
Functional Studies - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)
  • FuncS

Unknown

Functional Studies - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)

ab66047 staining serotonin in SKNSH cells treated with fluoxetine hydrochloride (ab120077), by ICC/IF. Increase of serotonin expression correlates with increased concentration of fluoxetine hydrochloride, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120077 (fluoxetine hydrochloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66047 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 donkey anti-goat polyclonal antibody (ab96931) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)
  • Chemical Structure

Lab

Chemical Structure - Fluoxetine hydrochloride, 5-HT reuptake inhibitor (AB120077)

2D chemical structure image of ab120077, Fluoxetine hydrochloride, 5-HT reuptake inhibitor

Key facts

CAS number

56296-78-7

Purity

>99%

Form

Solid

form

Molecular weight

345.8 Da

Molecular formula

C<sub>1</sub><sub>7</sub>H<sub>1</sub><sub>9</sub>ClF<sub>3</sub>NO

PubChem

62857

Nature

Synthetic

Solubility

Soluble in water to 10 mM

Soluble in DMSO to 100 mM

Biochemical name

Fluoxetine hydrochloride

Biological description

Potent, selective 5-HT reuptake inhibitor. Antidepressant in vivo. Binds to rat and human 5-HT transporters with Ki values of 2 and 0.9-20 nM, respectively. Shows around 150-900-fold selectivity over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic and muscarinic receptors.

Canonical smiles

CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl

InChi

InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChiKey

GIYXAJPCNFJEHY-UHFFFAOYSA-N

IUPAC Name

N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine;hydrochloride

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Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Molecular psychiatry 29:1046-1062 PubMed38233467

2024

High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin.

Applications

Unspecified application

Species

Unspecified reactive species

Dotan Braun,Ayelet M Rosenberg,Elad Rabaniam,Ravid Haruvi,Dorel Malamud,Rani Barbara,Tomer Aiznkot,Berta Levavi-Sivan,Takashi Kawashima

Current protocols 1:e208 PubMed34406704

2021

Models of Depression: Unpredictable Chronic Mild Stress in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Mathieu Nollet

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:13619-28 PubMed26446216

2015

Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features.

Applications

Unspecified application

Species

Unspecified reactive species

M Isabel Aller,Valeria Pecoraro,Ana V Paternain,Santiago Canals,Juan Lerma

Journal of psychopharmacology (Oxford, England) 27:192-202 PubMed23118019

2012

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph J Casal-Dominguez,Mary Clark,John R Traynor,Stephen M Husbands,Sarah J Bailey

The Journal of general physiology 135:333-53 PubMed20231374

2010

P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.

Applications

Unspecified application

Species

Unspecified reactive species

Estelle Toulme,Angie Garcia,Damien Samways,Terrance M Egan,Monica J Carson,Baljit S Khakh

Neuroscience 167:456-74 PubMed20167261

2010

Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

S D Greenhill,R S G Jones
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