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MW 510.4 Da, Purity >97%. Potent dopamine D2/D1 receptor antagonist (Ki values are 0.4 (D2), 2.3 (D1), 1.4 (D3), 7.1 (D4) and 25 nM (D5)). Inhibits dopamine-induced increases in adenylate cyclase activity (Ki = 9 nM). Antipsychotic. Active *in vivo*.
Alternative names=Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, KCNH2_HUMAN, Kv11.1, LQT 2, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, SQT1, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, eag homolog, hERG-1
- CAS number
146-56-5
- Purity
> 97%
- Form
Solid
- Molecular weight
510.4 Da
- Molecular formula
C22H28Cl2F3N3OS
- PubChem identifier
67356
- Nature
Synthetic
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MW 510.4 Da, Purity >97%. Potent dopamine D2/D1 receptor antagonist (Ki values are 0.4 (D2), 2.3 (D1), 1.4 (D3), 7.1 (D4) and 25 nM (D5)). Inhibits dopamine-induced increases in adenylate cyclase activity (Ki = 9 nM). Antipsychotic. Active *in vivo*.
Alternative names=Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, KCNH2_HUMAN, Kv11.1, LQT 2, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, SQT1, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, eag homolog, hERG-1
Key facts
- CAS number
146-56-5
- Purity
> 97%
- Form
Solid
- Molecular weight
510.4 Da
- Molecular formula
C22H28Cl2F3N3OS
- PubChem identifier
67356
- Nature
Synthetic
- Biochemical name
Fluphenazine hydrochloride
- Biological description
Potent dopamine D2/D1 receptor antagonist (Ki values are 0.4 (D2), 2.3 (D1), 1.4 (D3), 7.1 (D4) and 25 nM (D5)). Inhibits dopamine-induced increases in adenylate cyclase activity (Ki = 9 nM). Antipsychotic. Active *in vivo*.
- Canonical SMILES
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
- InChI
InChI=1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H
- InChIKey
MBHNWCYEGXQEIT-UHFFFAOYSA-N
- IUPAC name
2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;dihydrochloride
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
Ambient
- Storage information
The product can be stored for up to 12 months
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