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AB120651

Fluvastatin sodium salt, HMG-CoA reductase inhibitor

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(1 Publication)

MW 433.45 g/mol, Purity >99%. Competitive HMG-CoA reductase inhibitor (IC50 = 40 - 100 nM in human and rat microsomes). Potent inhibitor of vascular smooth muscle cell proliferation in vitro (IC50 = 70 nM).
1 Images
Chemical Structure - Fluvastatin sodium salt, HMG-CoA reductase inhibitor (AB120651)
  • Chemical Structure

Lab

Chemical Structure - Fluvastatin sodium salt, HMG-CoA reductase inhibitor (AB120651)

2D chemical structure image of ab120651, Fluvastatin sodium salt, HMG-CoA reductase inhibitor

Key facts

CAS number

93957-55-2

Purity

>99%

Form

Solid

form

Molecular weight

433.45 g/mol

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>5</sub>FNNaO<sub>4</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in water to 50 mM

Biological description

Competitive HMG-CoA reductase inhibitor (IC50 = 40 - 100 nM in human and rat microsomes). Potent inhibitor of vascular smooth muscle cell proliferation in vitro (IC50 = 70 nM).

IUPAC Name

(±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Product protocols

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 37:110056 PubMed34818551

2021

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Madeleine Dorsch,Manuela Kowalczyk,Mélanie Planque,Geronimo Heilmann,Sebastian Urban,Philip Dujardin,Jan Forster,Kristina Ueffing,Silke Nothdurft,Sebastian Oeck,Annika Paul,Sven T Liffers,Farnusch Kaschani,Markus Kaiser,Alexander Schramm,Jens T Siveke,Monte M Winslow,Sarah-Maria Fendt,Perihan Nalbant,Barbara M Grüner
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