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MW 452.4 Da, Purity >98%. Potent PP2A and PP4 inhibitor (IC50 values are 3.2 and 3 nM, respectively). Inhibits topoisomerase II (IC50 = 40 μM). Weakly inhibits PP1 (IC50 = 131 μM). Induces cell cycle arrest at G2-M-phase. Shows anti-ischemic, antitumor and antibiotic effects in vivo. Centrally active.

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Images

Chemical Structure - Fostriecin, PP2A and PP4 inhibitor (AB144255), expandable thumbnail

Key facts

CAS number
87860-39-7
Purity
> 98%
Form
Powder
Source
Streptomyces pulveraceous
Molecular weight
452.4 Da
Molecular formula
C19H26NaO9P
PubChem identifier
16759606
Nature
Native

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MW 452.4 Da, Purity >98%. Potent PP2A and PP4 inhibitor (IC50 values are 3.2 and 3 nM, respectively). Inhibits topoisomerase II (IC50 = 40 μM). Weakly inhibits PP1 (IC50 = 131 μM). Induces cell cycle arrest at G2-M-phase. Shows anti-ischemic, antitumor and antibiotic effects in vivo. Centrally active.

Key facts

Purity
> 98%
Source
Streptomyces pulveraceous
PubChem identifier
16759606
Solubility

Soluble in water to 100 mM.

Soluble in ethanol to 10 mM.

Biochemical name
Fostriecin sodium
Biological description

Potent PP2A and PP4 inhibitor (IC50 values are 3.2 and 3 nM, respectively). Inhibits topoisomerase II (IC50 = 40 μM). Weakly inhibits PP1 (IC50 = 131 μM). Induces cell cycle arrest at G2-M-phase. Shows anti-ischemic, antitumor and antibiotic effects in vivo. Centrally active.

Canonical SMILES
CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
Isomeric SMILES
C[C@@](/C=C/[C@H]1CC=CC(=O)O1)([C@@H](C[C@H](/C=C\C=C/C=C/CO)O)OP(=O)(O)[O-])O.[Na+]
InChI
InChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1/b3-2-,6-4+,8-5-,12-11+;/t15-,16+,17+,19+;/m0./s1
InChIKey
XBUIKNRVGYFSHL-IAVQPKKASA-M
IUPAC name
sodium;[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] hydrogen phosphate

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Fostriecin, PP2A and PP4 inhibitor (ab144255), expandable thumbnail

    Chemical Structure - Fostriecin, PP2A and PP4 inhibitor (ab144255)

    2D chemical structure image of ab144255, Fostriecin, PP2A and PP4 inhibitor

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Product protocols

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