MW 452.4 Da, Purity >98%. Potent PP2A and PP4 inhibitor (IC50 values are 3.2 and 3 nM, respectively). Inhibits topoisomerase II (IC50 = 40 μM). Weakly inhibits PP1 (IC50 = 131 μM). Induces cell cycle arrest at G2-M-phase. Shows anti-ischemic, antitumor and antibiotic effects in vivo. Centrally active.
MW 452.4 Da, Purity >98%. Potent PP2A and PP4 inhibitor (IC50 values are 3.2 and 3 nM, respectively). Inhibits topoisomerase II (IC50 = 40 μM). Weakly inhibits PP1 (IC50 = 131 μM). Induces cell cycle arrest at G2-M-phase. Shows anti-ischemic, antitumor and antibiotic effects in vivo. Centrally active.
Soluble in water to 100 mM.
Soluble in ethanol to 10 mM.
Potent PP2A and PP4 inhibitor (IC50 values are 3.2 and 3 nM, respectively). Inhibits topoisomerase II (IC50 = 40 μM). Weakly inhibits PP1 (IC50 = 131 μM). Induces cell cycle arrest at G2-M-phase. Shows anti-ischemic, antitumor and antibiotic effects in vivo. Centrally active.
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2D chemical structure image of ab144255, Fostriecin, PP2A and PP4 inhibitor
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