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MW 379.5 Da, Purity >98%. Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo. .

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Images

Chemical Structure - Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent (AB144258), expandable thumbnail

Publications

Key facts

CAS number
118974-02-0
Purity
> 98%
Form
Solid
Source
Aspergillus fumigatus
Molecular weight
379.5 Da
Molecular formula
C22H25N3O3
PubChem identifier
403923
Nature
Native

Target data

Alternative names

ABC transporter, ABC15, ABCG2_HUMAN, ABCP, ATP binding cassette sub family G (WHITE) member 2, ATP binding cassette transporter G2, ATP-binding cassette sub-family G member 2, BCRP, BCRP 1, BMDP, Breast cancer resistance protein, CD338, CDw338, CDw338 antigen, EST157481, GOUT1, MGC102821, MRX, MXR, MXR1, Mitoxantrone resistance-associated protein, Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2, Placenta specific MDR protein, Placenta-specific ATP-binding cassette transporter, UAQTL1

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MW 379.5 Da, Purity >98%. Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo. .

Key facts

Purity
> 98%
Source
Aspergillus fumigatus
PubChem identifier
403923
Solubility

Soluble in DMSO to 10 mM.

Biochemical name
Fumitremorgin C
Biological description

Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo.

Canonical SMILES
CC(=CC1C2=C(CC3N1C(=O)C4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
Isomeric SMILES
CC(=C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H]4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
InChI
InChI=1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1
InChIKey
DBEYVIGIPJSTOR-FHWLQOOXSA-N
IUPAC name
(1S,12S,15S)-7-methoxy-12-(2-methylprop-1-enyl)-10,13,19-triazapentacyclo[11.7.0.03,11.04,9.015,19]icosa-3(11),4(9),5,7-tetraene-14,20-dione

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months

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1 product image

  • Chemical Structure - Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent (ab144258), expandable thumbnail

    Chemical Structure - Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent (ab144258)

    2D chemical structure image of ab144258, Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent

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