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AB144258

Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent

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(1 Publication)

MW 379.5 Da, Purity >98%. Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo. .

View Alternative Names

ABC transporter, ABC15, ABCG2_HUMAN, ABCP, ATP binding cassette sub family G (WHITE) member 2, ATP binding cassette transporter G2, ATP-binding cassette sub-family G member 2, BCRP, BCRP 1, BMDP, Breast cancer resistance protein, CD338, CDw338, CDw338 antigen, EST157481, GOUT1, MGC102821, MRX, MXR, MXR1, Mitoxantrone resistance-associated protein, Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2, Placenta specific MDR protein, Placenta-specific ATP-binding cassette transporter, UAQTL1

1 Images
Chemical Structure - Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent (AB144258)
  • Chemical Structure

Lab

Chemical Structure - Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent (AB144258)

2D chemical structure image of ab144258, Fumitremorgin C (Tryptoquivaline), Chemosensitizing agent

Key facts

CAS number

118974-02-0

Purity

>98%

Form

Solid

form

Source

Aspergillus fumigatus

Molecular weight

379.5 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>5</sub>N<sub>3</sub>O<sub>3</sub>

PubChem

403923

Nature

Native

Solubility

Soluble in DMSO to 10 mM

Biochemical name

Fumitremorgin C

Biological description

Chemosensitizing agent. Potent and selective BCRP inhibitor. Selective AKT inhibitor. Selectively reverses resistance to and potentiates mitoxantrone (ab145668), doxorubicin (ab120629) and topotecan (ab120388) in BCRP-transfected cells. Mycotoxin. Shows antiproliferative effects. Shows tremorgenic effects in vivo.

Canonical smiles

CC(=CC1C2=C(CC3N1C(=O)C4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C

Isomeric smiles

CC(=C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H]4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C

InChi

InChI=1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1

InChiKey

DBEYVIGIPJSTOR-FHWLQOOXSA-N

IUPAC Name

(1S,12S,15S)-7-methoxy-12-(2-methylprop-1-enyl)-10,13,19-triazapentacyclo[11.7.0.03,11.04,9.015,19]icosa-3(11),4(9),5,7-tetraene-14,20-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 9:5695 PubMed30952903

2019

High Skp2 expression is associated with a mesenchymal phenotype and increased tumorigenic potential of prostate cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Šárka Šimečková,Zuzana Kahounová,Radek Fedr,Ján Remšík,Eva Slabáková,Tereza Suchánková,Jiřina Procházková,Jan Bouchal,Gvantsa Kharaishvili,Milan Král,Petr Beneš,Karel Souček
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Complementary Products

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RabMAb|Recombinant|KO Validated

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Secondary Antibodies

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Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

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Biochemicals

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Biochemicals

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Chemical Structure - Docetaxel, Cytotoxic agent (AB141248)

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