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AB120426

Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist

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(2 Publications)

MW 176.6 Da, Purity >98%. GABAA receptor agonist and GABAC receptor antagonist. Antinociceptive, anticonvulsant and hypnotic agent. Blood-brain barrier permeable. Active *in vivo* and *in vitro*.
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Chemical Structure - Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist (AB120426)
  • Chemical Structure

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Chemical Structure - Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist (AB120426)

2D chemical structure image of ab120426, Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist

Key facts

CAS number

85118-33-8

Purity

>98%

Form

Solid

form

Molecular weight

176.6 Da

Molecular formula

C<sub>6</sub>H<sub>9</sub>ClN<sub>2</sub>O<sub>2</sub>

PubChem

5702253

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 100 mM

Biochemical name

Gaboxadol hydrochloride

Biological description

GABAA receptor agonist and GABAC receptor antagonist. Antinociceptive, anticonvulsant and hypnotic agent. Blood-brain barrier permeable. Active *in vivo* and *in vitro*.

Canonical smiles

C1CNCC2=C1C(=O)NO2.Cl

InChi

InChI=1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H

InChiKey

ZDZDSZQYRBZPNN-UHFFFAOYSA-N

IUPAC Name

4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 33:108338 PubMed33147470

2020

Cerebellum-Specific Deletion of the GABA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Rudolph,Chong Guo,Stan L Pashkovski,Tomas Osorno,Winthrop F Gillis,Jeremy M Krauss,Hajnalka Nyitrai,Isabella Flaquer,Mahmoud El-Rifai,Sandeep Robert Datta,Wade G Regehr

Frontiers in neural circuits 7:186 PubMed24324406

2013

Distinct roles of synaptic and extrasynaptic GABAAreceptors in striatal inhibition dynamics.

Applications

Unspecified application

Species

Unspecified reactive species

Ruixi Luo,John G Partridge,Stefano Vicini
View all publications
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