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MW 364.4 Da, Purity >98%. Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.

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Images

Chemical Structure - Ganetespib (STA-9090) (AB273600), expandable thumbnail

Key facts

CAS number
888216-25-9
Purity
> 98%
Form
Solid
Molecular weight
364.4 Da
Molecular formula
C20H20N4O3
PubChem identifier
135564985
Nature
Synthetic

Target data

Recommended products

MW 364.4 Da, Purity >98%. Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.

Key facts

Purity
> 98%
PubChem identifier
135564985
Solubility

Soluble in DMSO to 100 mM.

Biochemical name
Ganetespib
Biological description

Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.

Canonical SMILES
CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O
InChI
InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)
InChIKey
RVAQIUULWULRNW-UHFFFAOYSA-N
IUPAC name
3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

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1 product image

  • Chemical Structure - Ganetespib (STA-9090) (ab273600), expandable thumbnail

    Chemical Structure - Ganetespib (STA-9090) (ab273600)

    Chemical structure of Ganetespib (STA-9090), 888216-25-9

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Product protocols

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