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AB273600

Ganetespib (STA-9090)

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MW 364.4 Da, Purity >98%. Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.
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Chemical Structure - Ganetespib (STA-9090) (AB273600)
  • Chemical Structure

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Chemical Structure - Ganetespib (STA-9090) (AB273600)

Chemical structure of Ganetespib (STA-9090), 888216-25-9

Key facts

CAS number

888216-25-9

Purity

>98%

Form

Solid

form

Molecular weight

364.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>0</sub>N<sub>4</sub>O<sub>3</sub>

PubChem

135564985

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Ganetespib

Biological description

Potent Hsp90 inhibitor (IC50 of 4nM in OSA 8 cells). Causes cytotoxicity in a variety of hematological and solid tumor cell lines by causing degradation of multiple oncogenic Hsp90 client proteins. Ganetespib inhibits MG63 cell lines with IC50 of 43 nM.

Canonical smiles

CC(C)C1=C(C=C(C(=C1)C2=NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)O)O

InChi

InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,25-26H,1-3H3,(H,22,27)

InChiKey

RVAQIUULWULRNW-UHFFFAOYSA-N

IUPAC Name

3-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-(1-methylindol-5-yl)-1H-1,2,4-triazol-5-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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Cell Lines & Lysates

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Advanced Validation

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