MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
67469-78-7
> 98%
Solid
523.5 Da
C28H34Cl2F2N2O
104920
Synthetic
MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
67469-78-7
> 98%
Solid
523.5 Da
C28H34Cl2F2N2O
104920
Synthetic
Soluble in water to 25 mM (with heating). Soluble in DMSO to 100 mM (with heating).
Vanoxerine dihydrochloride
Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
MIBSKSYCRFWIRU-UHFFFAOYSA-N
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride
Ambient - Can Ship with Ice
Ambient
Ambient
Store under desiccating conditions, The product can be stored for up to 12 months
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2D chemical structure image of ab120607, GBR 12909 dihydrochloride, Dopamine transport inhibitor
Anti-NMDAR2B antibody ab65783 staining NR2B in SKNSH cells treated with GBR 12909 dihydrochloride (ab120607), by ICC/IF. Decrease in NR2B expression correlates with increased concentration of GBR 12909 dihydrochloride, as described in literature.
The cells were incubated at 37°C for 10 minutes in media containing different concentrations of ab120607 (GBR 12909 dihydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-NMDAR2B antibody ab65783 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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