MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
Images
Publications
Filter by
- The Journal of neuroscience : the official journal of the Society for Neuroscience 31:262-722011μ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoost Wiskerke,Dustin Schetters,Inge E van Es,Yvar van Mourik,Bjørnar R O den Hollander,Anton N M Schoffelmeer,Tommy PattijPubMed 21209211
- Neuroscience 145:344-92007Nicotinic acetylcholine receptor antagonistic property of the selective dopamine uptake inhibitor, GBR-12909 in rat hippocampal slices.Applications:Unspecified applicationReactive species:Unspecified reactive speciesB K Szasz et. al.PubMed 17207584
- Neuroreport 14:1945-92003Inhibitory effect of the DA uptake blocker GBR 12909 on sodium channels of hippocampal neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesArpad Mike,Robert Karoly,E Sylvester Vizi,Janos P KissPubMed 14561926
Key facts
- CAS number
67469-78-7
- Purity
> 98%
- Form
Solid
- Molecular weight
523.5 Da
- Molecular formula
C28H34Cl2F2N2O
- PubChem identifier
104920
- Nature
Synthetic
Recommended products
MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
Key facts
- CAS number
67469-78-7
- Purity
> 98%
- Form
Solid
- Molecular weight
523.5 Da
- Molecular formula
C28H34Cl2F2N2O
- PubChem identifier
104920
- Nature
Synthetic
- Solubility
Soluble in water to 25 mM (with heating). Soluble in DMSO to 100 mM (with heating).
- Biochemical name
Vanoxerine dihydrochloride
- Biological description
Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
- Canonical SMILES
C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
- InChI
InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
- InChIKey
MIBSKSYCRFWIRU-UHFFFAOYSA-N
- IUPAC name
1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
Ambient
- Appropriate long-term storage conditions
Ambient
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Chemical Structure - GBR 12909 dihydrochloride, Dopamine transport inhibitor (ab120607)
2D chemical structure image of ab120607, GBR 12909 dihydrochloride, Dopamine transport inhibitor
Immunocytochemistry/ Immunofluorescence - GBR 12909 dihydrochloride, Dopamine transport inhibitor (ab120607)
Anti-NMDAR2B antibody ab65783 staining NR2B in SKNSH cells treated with GBR 12909 dihydrochloride (ab120607), by ICC/IF. Decrease in NR2B expression correlates with increased concentration of GBR 12909 dihydrochloride, as described in literature.
The cells were incubated at 37°C for 10 minutes in media containing different concentrations of ab120607 (GBR 12909 dihydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-NMDAR2B antibody ab65783 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com