MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
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Key facts
- CAS number
- 67469-78-7
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 523.5 Da
- Molecular formula
- C28H34Cl2F2N2O
- PubChem identifier
- 104920
- Nature
- Synthetic
Recommended products
MW 523.5 Da, Purity >98%. Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
Key facts
- CAS number
- 67469-78-7
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 523.5 Da
- Molecular formula
- C28H34Cl2F2N2O
- PubChem identifier
- 104920
- Nature
- Synthetic
- Solubility
Soluble in water to 25 mM (with heating).
Soluble in DMSO to 100 mM (with heating).
- Biochemical name
- Vanoxerine dihydrochloride
- Biological description
Potent, selective dopamine reuptake inhibitor (IC50 = 2.32 μM in rat hippocampal slices; IC50 = 6-35 μM in whole cell patch clamp recordings).
- Canonical SMILES
- C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl
- InChI
- InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
- InChIKey
- MIBSKSYCRFWIRU-UHFFFAOYSA-N
- IUPAC name
- 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - GBR 12909 dihydrochloride, Dopamine transport inhibitor (ab120607)
2D chemical structure image of ab120607, GBR 12909 dihydrochloride, Dopamine transport inhibitor
Immunocytochemistry/ Immunofluorescence - GBR 12909 dihydrochloride, Dopamine transport inhibitor (ab120607)
Anti-NMDAR2B antibody ab65783 staining NR2B in SKNSH cells treated with GBR 12909 dihydrochloride (ab120607), by ICC/IF. Decrease in NR2B expression correlates with increased concentration of GBR 12909 dihydrochloride, as described in literature.
The cells were incubated at 37°C for 10 minutes in media containing different concentrations of ab120607 (GBR 12909 dihydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-NMDAR2B antibody ab65783 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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