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AB273489

GDC0879

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MW 334.4 Da, Purity >98%. Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.
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Chemical Structure - GDC0879 (AB273489)
  • Chemical Structure

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Chemical Structure - GDC0879 (AB273489)

Chemical structure of GDC0879, 905281-76-7

Key facts

CAS number

905281-76-7

Purity

>98%

Form

Solid

form

Molecular weight

334.4 Da

Molecular formula

C<sub>1</sub><sub>9</sub>H<sub>1</sub><sub>8</sub>N<sub>4</sub>O<sub>2</sub>

PubChem

11717001

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

Biological description

Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.

Canonical smiles

C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO

Isomeric smiles

C1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO

InChi

InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18+

InChiKey

DEZZLWQELQORIU-RELWKKBWSA-N

IUPAC Name

2-[4-[(1E)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol

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Product details

For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
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Product protocols

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