Skip to main content

MW 334.4 Da, Purity >98%. Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.

Be the first to review this product! Submit a review

Images

Chemical Structure - GDC0879 (AB273489), expandable thumbnail

Key facts

CAS number
905281-76-7
Purity
> 98
Form
Solid
Molecular weight
334.4 Da
Molecular formula
C19H18N4O2
PubChem identifier
11717001
Nature
Synthetic

Target data

Recommended products

MW 334.4 Da, Purity >98%. Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.

Key facts

Purity
> 98
PubChem identifier
11717001
Solubility

Soluble in DMSO to 50 mM.

Biochemical name
(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime
Biological description

Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf/MEK/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.

Canonical SMILES
C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO
Isomeric SMILES
C1C/C(=N\O)/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO
InChI
InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18+
InChIKey
DEZZLWQELQORIU-RELWKKBWSA-N
IUPAC name
2-[4-[(1E)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C

Notes

For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - GDC0879 (ab273489), expandable thumbnail

    Chemical Structure - GDC0879 (ab273489)

    Chemical structure of GDC0879, 905281-76-7

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com