Gefitinib, EGFR tyrosine kinase inhibitor

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MW 446.9 Da, Purity >98%. Orally active, potent, selective EGFR (Epidermal growth factor receptor) tyrosine kinase inhibitor (IC₅₀ = 33 nM). Inhibits EGF-stimulated EGFR autophosphorylation and inhibits tumor growth in vivo. Enhances efficacy of cytotoxic agents. Inhibits growth factor production and angiogenesis. Clinically useful anticancer agent.

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Alpha-PAK, B55, Beta PAK, CAM kinase II delta, CAMK 2, CAMK 2B, CAMK 2d, CAMK2G, CAMKA, CDKN1A, CaM kinase II, CaM kinase II alpha, CaM kinase II beta, CaM kinase II gamma, CaM kinase II subunit alpha, CaMK-II subunit alpha, Calcium / calmodulin dependent protein kinase II delta, Calcium/calmodulin dependent protein kinase II gamma, Calcium/calmodulin-dependent protein kinase II-alpha, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Camk2a, EC 2.7.11.1, GCK family kinase MiNK, GSD9C, Gamma-PAK, Germinal center kinase like kinase, Germinal center kinase-related protein kinase, KCC2A_HUMAN, KHS, Kinase homologous to SPS1/STE20, MAP4K3, MAPK/ERK kinase kinase kinase 3, MAPK/ERK kinase kinase kinase 5, MAPK/ERK kinase kinase kinase 6, MAPKKKK3, MEK (MAP/ERK) kinase kinase 6, MEK kinase kinase 3, MEK kinase kinase 5, MEK kinase kinase 6, MEKKK 3, MEKKK 5, MEKKK6, MGC21111, MINK, MRX30, MRX47, Misshapen NIKs Related kinase, Misshapen like kinase 1, Misshapen/NIK related kinase, Mitogen activated protein kinase kinase kinase kinase 6, OPHN3, Oligophrenin 3, P21 (CDKN1A) activated kinase 2, P21 (CDKN1A) activated kinase 3, P21 protein (Cdc42/Rac) activated kinase 1, P21 protein (Cdc42/Rac) activated kinase 3, P21/Cdc42/Rac1 activated kinase 1 (yeast Ste20 related), P58, PAK alpha, PAK3beta, PAK65, PAKgamma, PHK gamma LT, PHK gamma T, PSK C3, Phosphorylase b kinase gamma catalytic chain testis/liver isoform, Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, Phosphorylase kinase catalytic subunit gamma 2, Phosphorylase kinase gamma subunit 2, Phosphorylase kinase subunit gamma 2, Phosphorylase kinase, gamma 2 (testis), Phosphorylase kinase, gamma 2 (testis/liver), RAB8IPL1, RP23-122P1.6, S6/H4 kinase, STE20 homolog, yeast, Serine/threonine protein kinase PAK 2, Serine/threonine protein kinase PAK 3, Serine/threonine protein kinase PHKG2, Serine/threonine-protein kinase PAK 1, TUBA1, TUBA1A, TUBA2, TUBA3, TUBA3C, TUBA4A, Tubulin, alpha 1a, Tubulin, alpha 3c, Tubulin, alpha 4a, Ysk2, ZC3, bPAK, calcium/calmodulin-dependent protein kinase II beta, hMINK, hPAK3, mitogen-activated protein kinase kinase kinase kinase 3, p21 activated kinase 3, p21 protein (Cdc42/Rac)-activated kinase 2, p21-activated kinase 1, p21-activated kinase 2, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast), p65-PAK