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AB145657

Gemcitabine, Cytidine analog

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(1 Publication)

MW 263.2 Da, Purity >98%. Cytidine analog. Antimetabolite. Induces apoptosis. Blocks cytosine nucleotide conversion into the deoxy derivative and blocks incorporation of the thymidine nucleotide into the DNA strand. Shows antitumor effects in vivo. .
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Chemical Structure - Gemcitabine, Cytidine analog (AB145657)
  • Chemical Structure

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Chemical Structure - Gemcitabine, Cytidine analog (AB145657)

2D chemical structure image of ab145657, Gemcitabine, Cytidine analog

Key facts

CAS number

95058-81-4

Purity

>98%

Form

Solid

form

Molecular weight

263.2 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>1</sub>F<sub>2</sub>N<sub>3</sub>O<sub>4</sub>

PubChem

60750

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Gemcitabine

Biological description

Cytidine analog. Antimetabolite. Induces apoptosis. Blocks cytosine nucleotide conversion into the deoxy derivative and blocks incorporation of the thymidine nucleotide into the DNA strand. Shows antitumor effects in vivo.

Canonical smiles

C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F

Isomeric smiles

C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F

InChi

InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1

InChiKey

SDUQYLNIPVEERB-QPPQHZFASA-N

IUPAC Name

4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancers 16: PubMed38927890

2024

Combined Treatment of Uterine Leiomyosarcoma with Gamma Secretase Inhibitor MK-0752 and Chemotherapeutic Agents Decreases Cellular Invasion and Increases Apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Yasmin Abedin,Alexander Fife,Cherie-Ann Samuels,Rasheena Wright,Trystn Murphy,Xusheng Zhang,Emily Alpert,Emma Cheung,Qingshi Zhao,Mark H Einstein,Nataki C Douglas
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