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AB141431

Gemcitabine hydrochloride, Deoxycytidine analog

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MW 299.66 Da, Purity >99%. Potent specific, deoxycytidine analog. Pro-drug phosphorylated by deoxycytidine kinase to gemcitabine diphosphate (dFdCDP) and triphosphate (dFdCTP). Cell cycle specific, inhibits the S and G1 phase. Antitumor activity in vitro and in vivo.
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Chemical Structure - Gemcitabine hydrochloride, Deoxycytidine analog (AB141431)
  • Chemical Structure

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Chemical Structure - Gemcitabine hydrochloride, Deoxycytidine analog (AB141431)

2D chemical structure image of ab141431, Gemcitabine hydrochloride, Deoxycytidine analog

Key facts

CAS number

122111-03-9

Purity

>99%

Form

Solid

form

Molecular weight

299.66 Da

Molecular formula

C<sub>9</sub>H<sub>1</sub><sub>2</sub>ClF<sub>2</sub>N<sub>3</sub>O<sub>4</sub>

PubChem

60749

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Soluble in DMSO to 50 mM

Biochemical name

Gemcitabine hydrochloride

Biological description

Potent specific, deoxycytidine analog. Pro-drug phosphorylated by deoxycytidine kinase to gemcitabine diphosphate (dFdCDP) and triphosphate (dFdCTP). Cell cycle specific, inhibits the S and G1 phase. Antitumor activity in vitro and in vivo.

Canonical smiles

C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl

Isomeric smiles

C1=CN(C(=O)N=C1N)[C@H]2C([C@@H]([C@H](O2)CO)O)(F)F.Cl

InChi

InChI=1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1

InChiKey

OKKDEIYWILRZIA-OSZBKLCCSA-N

IUPAC Name

4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Product promise

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