MW 226.23 g/mol, Purity >99%. Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
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Key facts
- CAS number
- 6902-77-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 226.23 g/mol
- Molecular formula
- C11H14O5
- Nature
- Synthetic
Recommended products
MW 226.23 g/mol, Purity >99%. Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
Key facts
- CAS number
- 6902-77-8
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 226.23 g/mol
- Molecular formula
- C11H14O5
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 50 mM.
- Biological description
Cell-permeable uncoupling protein 2 (UCP2) inhibitor. Anti-inflammatory, anti-angiogenic and pro-apototic effects. Acts as a protein cross-linker.
- Isomeric SMILES
- O=C(OC)C1=CO[C@@H](O)[C@@H]2C(=CC[C@H]12)CO
- InChI
- InChI=1S/C11H14O5/c1-15-10(13)8-5-16-11(14)9-6(4-12)2-3-7(8)9/h2,5,7,9,11-12,14H,3-4H2,1H3/t7-,9-,11-/m1/s1
- InChIKey
- AZKVWQKMDGGDSV-BCMRRPTOSA-N
- IUPAC name
- (1R,4aS,7aS)-1,4a,5,7a-Tetrahydro-1-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid methyl ester
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- The product can be stored for up to 12 months
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2 product images
Chemical Structure - Genipin, Cell-permeable uncoupling protein 2 inhibitor (ab141049)
2D chemical structure image of ab141049, Genipin, Cell-permeable uncoupling protein 2 inhibitor
Functional Studies - Genipin, Cell-permeable uncoupling protein 2 inhibitor (ab141049)
Anti-p53 antibody [PAb 1801] ab28 staining p53 in HeLa cells treated with genipin (ab141049), by ICC/IF. Increase of p53 expression correlates with increased concentration of genipin, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab141049 (genipin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-p53 antibody [PAb 1801] ab28 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (Goat Anti-Mouse IgG H&L (DyLight® 488) preadsorbed ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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