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AB120112

Genistein, Protein tyrosine kinase inhibitor

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(10 Publications)

MW 270.24 Da, Purity >99%. Phytoestrogen found in soy beans. Anticancer agent. Inihibits tyrosine protein kinase and DNA topoisomerase as well as possessing antioxidant and cell cycle inhibitor activity. Endocytosis inhibitor.
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Chemical Structure - Genistein, Protein tyrosine kinase inhibitor (AB120112)
  • Chemical Structure

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Chemical Structure - Genistein, Protein tyrosine kinase inhibitor (AB120112)

2D chemical structure image of ab120112, Genistein, Protein tyrosine kinase inhibitor

Key facts

CAS number

446-72-0

Purity

>99%

Form

Solid

form

Molecular weight

270.24 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>0</sub>O<sub>5</sub>

PubChem

5280961

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Genistein

Biological description

Phytoestrogen found in soy beans. Anticancer agent. Inihibits tyrosine protein kinase and DNA topoisomerase as well as possessing antioxidant and cell cycle inhibitor activity. Endocytosis inhibitor.

Canonical smiles

C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O

InChi

InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

InChiKey

TZBJGXHYKVUXJN-UHFFFAOYSA-N

IUPAC Name

5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

Biomolecules 13: PubMed36830711

2023

Novel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System.

Applications

Unspecified application

Species

Unspecified reactive species

Marine Houdou,Nathalie Jacobs,Jonathan Coene,Mujahid Azfar,Roeland Vanhoutte,Chris Van den Haute,Jan Eggermont,Veronique Daniëls,Steven H L Verhelst,Peter Vangheluwe

International journal of molecular sciences 24: PubMed36674745

2023

Adipose Tissue-Derived Extracellular Vesicles Contribute to Phenotypic Plasticity of Prostate Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Allison Mathiesen,Bronson Haynes,Ryan Huyck,Michael Brown,Anca Dobrian

Frontiers in cellular neuroscience 16:860823 PubMed35783090

2022

Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide.

Applications

Unspecified application

Species

Unspecified reactive species

Johannes Piepgras,Astrid Rohrbeck,Ingo Just,Stefan Bittner,Gudrun Ahnert-Hilger,Markus Höltje

Frontiers in immunology 11:583644 PubMed33408714

2020

Extracellular Vesicles Modulate Gut Epithelial Cell Innate Immunity FomA and TLR2.

Applications

Unspecified application

Species

Unspecified reactive species

Camille Martin-Gallausiaux,Antoine Malabirade,Janine Habier,Paul Wilmes

The Journal of biological chemistry 296:100182 PubMed33310703

2020

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system.

Applications

Unspecified application

Species

Unspecified reactive species

Norin Nabil Hamouda,Chris Van den Haute,Roeland Vanhoutte,Ragna Sannerud,Mujahid Azfar,Rupert Mayer,Álvaro Cortés Calabuig,Johannes V Swinnen,Patrizia Agostinis,Veerle Baekelandt,Wim Annaert,Francis Impens,Steven H L Verhelst,Jan Eggermont,Shaun Martin,Peter Vangheluwe

Nature 578:419-424 PubMed31996848

2020

ATP13A2 deficiency disrupts lysosomal polyamine export.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah van Veen,Shaun Martin,Chris Van den Haute,Veronick Benoy,Joseph Lyons,Roeland Vanhoutte,Jan Pascal Kahler,Jean-Paul Decuypere,Géraldine Gelders,Eric Lambie,Jeffrey Zielich,Johannes V Swinnen,Wim Annaert,Patrizia Agostinis,Bart Ghesquière,Steven Verhelst,Veerle Baekelandt,Jan Eggermont,Peter Vangheluwe

Experimental parasitology 185:115-123 PubMed29331278

2018

Impact of treatment with a Protein Tyrosine Kinase Inhibitor (Genistein) on acute and chronic experimental Schistosoma mansoni infection.

Applications

Unspecified application

Species

Unspecified reactive species

Maysa Mohamed Kamel Sobhy,Soheir Sayed Mahmoud,Shaimaa Helmy El-Sayed,Enas Mohamed Ali Rizk,Amira Raafat,Mohamed Sherif Ismail Negm

OncoTargets and therapy 10:5405-5415 PubMed29180873

2017

In vitro study on anti-cancer properties of genistein in tongue cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fatima Ardito,Mario R Pellegrino,Donatella Perrone,Giuseppe Troiano,Armando Cocco,Lorenzo Lo Muzio

Pharmacological research 66:309-16 PubMed22743170

2012

The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder.

Applications

Unspecified application

Species

Unspecified reactive species

A Valeri,P Fiorenzani,R Rossi,A M Aloisi,M Valoti,F Pessina

Journal of the American Chemical Society 132:9789-96 PubMed20586450

2010

Hairpin DNA-functionalized gold colloids for the imaging of mRNA in live cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ashwath Jayagopal,Kristin C Halfpenny,Jonas W Perez,David W Wright
View all publications
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