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AB286986

Genz-123346

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MW 418.6 Da, Purity >98%. Potent and selective glucosylceramide synthase inhibitor with potential anticancer activity.

Does not affect the activities of other related glycosidase, such as 1-Oacylceramide synthase, a-glucosidase, and glucocerebrosidase in any significant manner.

Shown to improve glucose tolerance, improve insulin sensitivity, and normalize hemoglobin A1C levels in Zucker diabetic fatty rats.

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View Alternative Names

CEGT_HUMAN, Ceramide glucosyltransferase, GCS, GLCT-1, Glucosylceramide synthase, UDP glucose N acylsphingosine D glucosyltransferase, UDP-glucose ceramide glucosyltransferase, UDP-glucose:N-acylsphingosine D-glucosyltransferase, Ugcg

Key facts

CAS number

491833-30-8

Purity

>98%

Form

Solid

form

Molecular weight

418.6 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>3</sub><sub>8</sub>N<sub>2</sub>O<sub>4</sub>

PubChem

23652732

Nature

Synthetic

Solubility

DMSO

Biochemical name

Genz-123346 free base

Biological description

Potent and selective glucosylceramide synthase inhibitor with potential anticancer activity.

Does not affect the activities of other related glycosidase, such as 1-Oacylceramide synthase, a-glucosidase, and glucocerebrosidase in any significant manner.

Shown to improve glucose tolerance, improve insulin sensitivity, and normalize hemoglobin A1C levels in Zucker diabetic fatty rats.

Canonical smiles

CCCCCCCCC(=O)NC(CN1CCCC1)C(C2=CC3=C(C=C2)OCCO3)O

Isomeric smiles

CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@@H](C2=CC3=C(C=C2)OCCO3)O

InChi

InChI=1S/C24H38N2O4/c1-2-3-4-5-6-7-10-23(27)25-20(18-26-13-8-9-14-26)24(28)19-11-12-21-22(17-19)30-16-15-29-21/h11-12,17,20,24,28H,2-10,13-16,18H2,1H3,(H,25,27)/t20-,24-/m1/s1

InChiKey

JMNXWOFCUJJYEO-HYBUGGRVSA-N

IUPAC Name

N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]nonanamide

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called B2286 genz-123346. B2286-10 is the same size as the 10 mg size of ab286986.
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
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Product protocols

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