GF 109203X (Bisindolylmaleimide i), PKC inhibitor

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(4 Publications)

MW 412.5 Da, Purity >98%. Potent, selective PKC inhibitor (IC₅₀ values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Potent GSK-3 inhibitor (IC₅₀ = 360 nM). Potent 5-HT3 antagonist (K_i = 29.5 nM). Shows anti-inflammatory effects in vivo. .

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AI327039, B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, CCND1/FSTL3 fusion gene, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, CCND1/PTH fusion gene, included, CCND1_HUMAN, CD1, CDK4 protein, CDK4_HUMAN, CMM 3, CVID9, Cell division kinase 4, Cell division protein kinase 4, Crk3, Cyclin-dependent kinase 4, Cyl 1, D11S287E, D14Ertd420e, ERK-2, ERT1, Eag-related protein 1, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, Extracellular signal-regulated kinase 2, G1/S-specific cyclin-D1, GSK-3 beta, GSK3B_HUMAN, GSK3beta isoform, Glycogen synthase kinase-3 beta, H-ERG, KCNH2_HUMAN, KPCA_HUMAN, KPCB_HUMAN, KPCD_HUMAN, KPCE_HUMAN, KPCG_HUMAN, KPCL_HUMAN, KPCT_HUMAN, Kinase PKC delta, Kv11.1, LQT 2, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, May-01, MGC 5363, MGC125656, MGC125657, MGC126514, MGC141919, MGC14458, MGC26269, MGC49908, MGC57564, MK01_HUMAN, Melanoma cutaneous malignant 3, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, OTTHUMP00000043364, OTTHUMP00000043365, OTTHUMP00000067291, Oncogene PIM 1, P38, P41, PCKd, PIM, PIM1_HUMAN, PKC 0, PKC 2, PKC ZETA, PKC d, PKC delta, PKC epsilon, PKC h, PKC-A, PKC-B, PKC-L, PKC-alpha, PKC-beta, PKC-gamma, PKCC, PKCE, PKCG, PRAD1, PRAD1 oncogene, PRKC D, PRKC delta, PRKCA, PRKCB, PRKCB II, PRKCB1, PRKCB2, PRKCE, PRKCG, PRKCL, PRKCT, PRKCZ, PRKM 2, PRKM1, PSK-J3, Parathyroid adenomatosis 1, Pim 1 kinase, Pim 1 oncogene, Pkcea, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Prkch, Prkcq, Protein Kinase C alpha, Protein Kinase C delta, Protein kinase C, Protein kinase C alpha type, Protein kinase C beta, Protein kinase C beta type, Protein kinase C delta VIII, Protein kinase C delta type, Protein kinase C epsilon, Protein kinase C epsilon type, Protein kinase C eta, Protein kinase C eta type, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C theta, Protein kinase C theta type, Protein kinase C zeta, Proto-oncogene serine/threonine-protein kinase Pim-1, Proviral integration site 1, Proviral integration site 2, SCA 14, SQT1, Serine/threonine-protein kinase GSK3B, Tyrosine protein kinase PRKCD, U21B31, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, eag homolog, hERG-1, nPKC-delta, nPKC-epsilon, nPKC-eta, nPKC-theta, p34 cdk4, p42-MAPK, pim 1 kinase 44 kDa isoform, pim 1 oncogene (proviral integration site 1), protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2