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AB120844

GF 109203X hydrochloride, ATP-competitive PKC inhibitor

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(1 Publication)

MW 448.9 Da, Purity >99%. Potent, cell-permeable, ATP-competitive PKC inhibitor (IC50 values for PKC subtypes are 50 (α), 17 (βI), 16 (βII) and 20 nM (γ)). Inhibits PKC over other kinases (IC50 values are 50 nM (MAPKAP), 100 nM (p70 S6 kinase), 2 μM (cAMP-dependent protein kinase) and 0.7 μM (phosphorylase kinase)). Crosses the blood-brain barrier.
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Chemical Structure - GF 109203X hydrochloride, ATP-competitive PKC inhibitor (AB120844)
  • Chemical Structure

Lab

Chemical Structure - GF 109203X hydrochloride, ATP-competitive PKC inhibitor (AB120844)

2D chemical structure image of ab120844, GF 109203X hydrochloride, ATP-competitive PKC inhibitor

Key facts

CAS number

176504-36-2

Purity

>99%

Form

Solid

form

Molecular weight

448.9 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>2</sub><sub>5</sub>ClN<sub>4</sub>O<sub>2</sub>

PubChem

6419775

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Bisindolylmaleimide I HCl

Biological description

Potent, cell-permeable, ATP-competitive PKC inhibitor (IC50 values for PKC subtypes are 50 (α), 17 (βI), 16 (βII) and 20 nM (γ)). Inhibits PKC over other kinases (IC50 values are 50 nM (MAPKAP), 100 nM (p70 S6 kinase), 2 μM (cAMP-dependent protein kinase) and 0.7 μM (phosphorylase kinase)). Crosses the blood-brain barrier.

Canonical smiles

CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54.Cl

InChi

InChI=1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H

InChiKey

XRAMWNCMYJHGGH-UHFFFAOYSA-N

IUPAC Name

3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;hydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of neurochemistry 161:478-491 PubMed35583089

2022

Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala.

Applications

Unspecified application

Species

Unspecified reactive species

Hua Zhang,Zhao-Fu Sheng,Jingxiong Wang,PeiRu Zheng,XunLei Kang,Hui-Ming Chang,Edward T H Yeh,De-Pei Li
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