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AB142437

Gliotoxin, NF-kappaB inhibitor

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(3 Publications)

MW 326.4 Da, Purity >98%. Specfic NF-κB inhibitor. Induces apoptosis and suppresses TNF-α gene expression in vitro. Farnesyltransferase and geranylgeranyltransferase I inhibitor (IC50 = 80 and 17 μM respectively). Mycotoxin antibiotic. Immunosuppressive, anti-inflammatory and antitumor agent. Active in vivo and in vitro. Orally active.
1 Images
Chemical Structure - Gliotoxin, NF-kappaB inhibitor (AB142437)
  • Chemical Structure

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Chemical Structure - Gliotoxin, NF-kappaB inhibitor (AB142437)

2D chemical structure image of ab142437, Gliotoxin, NF-kappaB inhibitor

Key facts

CAS number

67-99-2

Purity

>98%

Form

Solid

form

Molecular weight

326.4 Da

Molecular formula

C<sub>1</sub><sub>3</sub>H<sub>1</sub><sub>4</sub>N<sub>2</sub>O<sub>4</sub>S<sub>2</sub>

PubChem

6223

Nature

Synthetic

Solubility

Soluble in DMSO

Soluble in ethanol

Biochemical name

Gliotoxin

Biological description

Specfic NF-κB inhibitor. Induces apoptosis and suppresses TNF-α gene expression in vitro. Farnesyltransferase and geranylgeranyltransferase I inhibitor (IC50 = 80 and 17 μM respectively). Mycotoxin antibiotic. Immunosuppressive, anti-inflammatory and antitumor agent. Active in vivo and in vitro. Orally active.

Canonical smiles

CN1C(=O)C23CC4=CC=CC(C4N2C(=O)C1(SS3)CO)O

Isomeric smiles

CN1C(=O)[C@]23CC4=CC=C[C@@H]([C@H]4N2C(=O)[C@]1(SS3)CO)O

InChi

InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1

InChiKey

FIVPIPIDMRVLAY-RBJBARPLSA-N

IUPAC Name

(1R,7S,8S,11R)-7-hydroxy-11-(hydroxymethyl)-15-methyl-12,13-dithia-9,15-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,14-dione

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Complementary Products

Biochemicals

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Secondary Antibodies

AB150113

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Primary Antibodies

AB309104

Anti-RBCK1 antibody [EPR28157-53]

20ul selling size|KO Validated|RabMAb|Recombinant

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Biochemicals

AB141453

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

RNF31 also known as HOIP (HOIL-1-interacting protein) is a part of the linear ubiquitin chain assembly complex (LUBAC). It has a mass of approximately 119 kDa and plays an essential role in protein ubiquitination processes. This protein is actively expressed in various tissues including the spleen lung and lymphoid tissues. RNF31 collaborates with other proteins like SHARPIN and RBCK1 to modulate cellular responses.
Biological function summary

RNF31 contributes to the regulation of NF-κB signaling which is an important player in inflammation and immune responses. It is an important component of the LUBAC complex facilitating the linear ubiquitination of target proteins. Its activity influences the activation of NF-κB transcription factors which are important for controlling the expression of genes linked to immune and inflammatory reactions.

Pathways

The RNF31 protein is integral to the NF-κB signaling pathway as well as to apoptosis. It mediates modifications on proteins that ultimately result in NF-κB activation maintaining a balance between survival and cell death. In these functions RNF31 is closely related to SUV39H1 and other partners within these pathways which collectively influence transcriptional activity and cellular fate.

RNF31 has connections with inflammatory diseases and certain types of cancer. Abnormal regulation or expression of RNF31 and its associated proteins like SHARPIN might contribute to pathological conditions by disrupting normal immune responses. Understanding these connections offers potential therapeutic targets for conditions such as rheumatoid arthritis and various carcinomas.
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in microbiology 10:1345 PubMed31275272

2019

Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Into Type II Human Pneumocyte Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Changjian Zhang,Fangyan Chen,Xiaoyu Liu,Xuelin Han,Yingsong Hu,Xueting Su,Yong Chen,Yansong Sun,Li Han

Nature communications 10:273 PubMed30655516

2019

LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.

Applications

Unspecified application

Species

Unspecified reactive species

Min Wu,Yan Chang,Huaibin Hu,Rui Mu,Yucheng Zhang,Xuanhe Qin,Xiaotao Duan,Weihua Li,Haiqing Tu,Weina Zhang,Guang Wang,Qiuying Han,Ailing Li,Tao Zhou,Kazuhiro Iwai,Xuemin Zhang,Huiyan Li

Microbial pathogenesis 123:169-176 PubMed30017941

2018

Gliotoxin destructs the pulmonary epithelium barrier function by reducing cofilin oligomer formation to promote the dissolution of actin stress fibers.

Applications

Unspecified application

Species

Unspecified reactive species

Changjian Zhang,Xiaoyu Liu,Fangyan Chen,Yingsong Hu,Zhiqian Li,Yanxi Liu,Xuelin Han,Yansong Sun,Li Han
View all publications
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