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AB120845

GM 6001, MMP inhibitor

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(21 Publications)

GM 6001 (ab120845) is a broad spectrum, cell-permeable, potent matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14 and MMP-26. Moleculr weight: 388.5

- Pharmacologically active in vivo
- Available in different sizes to fit your experimental needs
1 Images
Chemical Structure - GM 6001, MMP inhibitor (AB120845)
  • Chemical Structure

Lab

Chemical Structure - GM 6001, MMP inhibitor (AB120845)

2D chemical structure image of ab120845, GM 6001, MMP inhibitor

Key facts

CAS number

142880-36-2

Purity

>98%

Form

Solid

form

Molecular weight

388.5 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>8</sub>N<sub>4</sub>O<sub>4</sub>

PubChem

132519

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Ilomastat

Biological description

Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

Canonical smiles

CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC

Isomeric smiles

CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC

InChi

InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

InChiKey

NITYDPDXAAFEIT-DYVFJYSZSA-N

IUPAC Name

(2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide

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Complementary Products

Assay Kits

AB112146

MMP Activity Assay Kit (Fluorometric - Green)

Functional Studies - MMP Activity Assay Kit (Fluorometric - Green) (AB112146)

  • 4
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Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 16
Biochemicals

AB142180

MMP-9 inhibitor

  • 0
  • 0
Biochemicals

AB142087

Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor

Chemical Structure - Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor (AB142087)

  • 0
  • 0
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Product details

Check out our range of MMP (Matrix Metalloproteinases) inhibitors here
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

MMPs play roles in conditions such as cancer metastasis and chronic inflammatory diseases like rheumatoid arthritis. During cancer progression MMPs such as MMP2 and MMP9 facilitate tumor invasion and the spread of cancer cells by breaking down basement membranes and stromal tissues. In arthritis MMPs lead to cartilage degradation causing joint damage. MMP inhibitors such as GM6001 have been explored to target these diseases by moderating excessive MMP activity presenting therapeutic potential for conditions exacerbated by uncontrolled proteolysis.
Pathways

MMPs operate within significant biological processes like the inflammatory response and cellular signaling pathways including the MAPK and NF-kB pathways. They interact with other proteins such as integrins and cytokines to modulate cellular and inflammatory responses. Such interactions impact the balance between matrix formation and degradation exemplifying their involvement in tissue homeostasis and response to injury or disease.

Biological function summary

MMPs facilitate the breakdown of extracellular matrix components impacting processes such as angiogenesis wound healing and embryonic development. They often work in concert with other proteins in the extracellular space potentially forming complexes with tissue inhibitors of metalloproteinases (TIMPs) which regulate their activity. MMPs not only maintain normal physiological function but also reactivate and remodel tissue structure during pathological conditions providing grounds for cellular migration and proliferation.

MMPs (Matrix Metalloproteinases) such as MMP1 MMP2 MMP3 MMP7 MMP8 MMP9 MMP12 MMP13 MMP14 MMP16 MT2-MMP MT4-MMP and MMP26 are enzymes that play roles in tissue remodeling and are known for degrading extracellular matrix proteins. They are often referred to as collagenases or gelatinases depending on their substrate specificity. MMPs originate from diverse tissues including the skin lung and connective tissues and they have wide-ranging molecular masses typically between 20 to 100 kDa. They can be expressed in response to cytokines growth factors and physical stress indicating their versatile roles across different tissue environments.
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Product protocols

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Publications (21)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:26248 PubMed39482373

2024

High-throughput Bronchus-on-a-Chip system for modeling the human bronchus.

Applications

Unspecified application

Species

Unspecified reactive species

Akina Mori,Marjolein Vermeer,Lenie J van den Broek,Jeroen Heijmans,Arnaud Nicolas,Josse Bouwhuis,Todd Burton,Kazushi Matsumura,Kazuhiro Ohashi,Shigeaki Ito,Bart Kramer

Nature communications 15:2861 PubMed38570505

2024

Age-progressive interplay of HSP-proteostasis, ECM-cell junctions and biomechanics ensures C. elegans astroglial architecture.

Applications

Unspecified application

Species

Unspecified reactive species

Francesca Coraggio,Mahak Bhushan,Spyridon Roumeliotis,Francesca Caroti,Carlo Bevilacqua,Robert Prevedel,Georgia Rapti

Development, growth & differentiation 66:133-144 PubMed38281811

2024

Macrophages enhance regeneration of lateral line neuromast derived from interneuromast cells through TGF-β in zebrafish.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Lin Hsu,Yu-Chi Lin,Meng-Ju Lin,Yi-Wen Wang,Shyh-Jye Lee

iScience 26:108211 PubMed37942007

2023

Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Man Guo,Daoqi Shen,Yiqi Su,Jiarui Xu,Shuan Zhao,Weidong Zhang,Yaqiong Wang,Wuhua Jiang,Jialin Wang,Xuemei Geng,Xiaoqiang Ding,Xialian Xu

Scientific reports 13:15508 PubMed37726363

2023

A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity.

Applications

Unspecified application

Species

Unspecified reactive species

Priya H Dedhia,Hemamylammal Sivakumar,Marco A Rodriguez,Kylie G Nairon,Joshua M Zent,Xuguang Zheng,Katie Jones,Liudmila V Popova,Jennifer L Leight,Aleksander Skardal

Journal of molecular cell biology 14: PubMed36271843

2023

The regenerative response of cardiac interstitial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Rolland,Alenca Harrington,Adèle Faucherre,Jourdano Mancilla Abaroa,Girisaran Gangatharan,Laurent Gamba,Dany Severac,Marine Pratlong,Thomas Moore-Morris,Chris Jopling

Science advances 9:eadd9275 PubMed36989370

2023

How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth.

Applications

Unspecified application

Species

Unspecified reactive species

Mario C Benn,Simon A Pot,Jens Moeller,Tadahiro Yamashita,Charlotte M Fonta,Gertraud Orend,Philip Kollmannsberger,Viola Vogel

Acta biomaterialia 155:167-181 PubMed36371004

2022

Self-assembly of mesoscale collagen architectures and applications in 3D cell migration.

Applications

Unspecified application

Species

Unspecified reactive species

Chang Liu,Ryan Y Nguyen,Gabriela A Pizzurro,Xingjian Zhang,Xiangyu Gong,Alejandro Rossello Martinez,Michael Mak

Journal of biomedical materials research. Part A 111:389-403 PubMed36210776

2022

Click chemistry functionalization of self-assembling peptide hydrogels.

Applications

Unspecified application

Species

Unspecified reactive species

Joe T Sharick,Angelina J Atieh,Keith J Gooch,Jennifer L Leight

Nature communications 13:1151 PubMed35241668

2022

Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8 mouse model of ASD-like behavior.

Applications

Unspecified application

Species

Unspecified reactive species

You Yu,Bing Zhang,Peifeng Ji,Zhenqiang Zuo,Yongxi Huang,Ning Wang,Chang Liu,Shuang-Jiang Liu,Fangqing Zhao
View all publications
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