Skip to main content

MW 388.5 Da, Purity >98%. Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

Be the first to review this product! Submit a review

Images

Key facts

CAS number

142880-36-2

Purity

> 98%

Form

Solid

Molecular weight

388.5 Da

Molecular formula

C20H28N4O4

PubChem identifier

132519

Nature

Synthetic

Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

Alternative names

Recommended products

  1. Loading...
  2. Loading...
  3. Loading...
  4. Loading...

MW 388.5 Da, Purity >98%. Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

Alternative names

Key facts

Purity

> 98%

PubChem identifier

132519

Biochemical name

Ilomastat

Biological description

Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

Canonical SMILES

CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC

Isomeric SMILES

CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC

InChI

InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

InChIKey

NITYDPDXAAFEIT-DYVFJYSZSA-N

IUPAC name

(2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

The product can be stored for up to 12 months

Supplementary info

Biological function summary

MMPs facilitate the breakdown of extracellular matrix components impacting processes such as angiogenesis wound healing and embryonic development. They often work in concert with other proteins in the extracellular space potentially forming complexes with tissue inhibitors of metalloproteinases (TIMPs) which regulate their activity. MMPs not only maintain normal physiological function but also reactivate and remodel tissue structure during pathological conditions providing grounds for cellular migration and proliferation.

Activity summary

MMPs (Matrix Metalloproteinases) such as MMP1 MMP2 MMP3 MMP7 MMP8 MMP9 MMP12 MMP13 MMP14 MMP16 MT2-MMP MT4-MMP and MMP26 are enzymes that play roles in tissue remodeling and are known for degrading extracellular matrix proteins. They are often referred to as collagenases or gelatinases depending on their substrate specificity. MMPs originate from diverse tissues including the skin lung and connective tissues and they have wide-ranging molecular masses typically between 20 to 100 kDa. They can be expressed in response to cytokines growth factors and physical stress indicating their versatile roles across different tissue environments.

Pathways

MMPs operate within significant biological processes like the inflammatory response and cellular signaling pathways including the MAPK and NF-kB pathways. They interact with other proteins such as integrins and cytokines to modulate cellular and inflammatory responses. Such interactions impact the balance between matrix formation and degradation exemplifying their involvement in tissue homeostasis and response to injury or disease.

Associated diseases and disorders

MMPs play roles in conditions such as cancer metastasis and chronic inflammatory diseases like rheumatoid arthritis. During cancer progression MMPs such as MMP2 and MMP9 facilitate tumor invasion and the spread of cancer cells by breaking down basement membranes and stromal tissues. In arthritis MMPs lead to cartilage degradation causing joint damage. MMP inhibitors such as GM6001 have been explored to target these diseases by moderating excessive MMP activity presenting therapeutic potential for conditions exacerbated by uncontrolled proteolysis.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

1 product image

  • Chemical Structure - GM 6001, MMP inhibitor (ab120845), expandable thumbnail

    Chemical Structure - GM 6001, MMP inhibitor (ab120845)

    2D chemical structure image of ab120845, GM 6001, MMP inhibitor

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

There was a problem

We can’t download that datasheet. Please try again. If you need help, contact our Customer Services team at technical@abcam.com