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MW 388.5 Da, Purity >98%. Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

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Key facts

CAS number

142880-36-2

Purity

> 98%

Form

Liquid

Molecular weight

388.5 Da

Molecular formula

C20H28N4O4

PubChem identifier

132519

Nature

Synthetic

Associated Products

Select an associated product type

1 product for Alternative Version

Target data

Alternative names

27 kDa interstitial collagenase, 72 kDa gelatinase, 72kD type IV collagenase, 82 kDa matrix metalloproteinase-9, 92 kDa gelatinase, 92 kDa type IV collagenase, AI503551, C8orf57, CHDS6, CLG, CLG 1, CLG 3, CLG 4, CLG 4A, CLG 4B, Collagenase 1, Collagenase 1 neutrophil, Collagenase 3, Collagenase Type 4 alpha, Collagenase Type 4 beta, Collagenase type IV 92 KD, Collagenase type IV A, DKFZp761D112, EC 3.4.24.35, EC 3.4.24.65, Endometase, Fibroblast collagenase, GELB, Gelatinase 92 KD, Gelatinase A, Gelatinase B, Gelatinase alpha, Gelatinase beta, Gelatinase neutrophil, HME, HNC, Interstitial collagenase, MANDP1, MANDP2, ME, MGC126102, MGC126103, MGC126104, MGC138506, MME, MMP II, MMP-X1, MMP-X2, MMP12_HUMAN, MMP13_HUMAN, MMP14_HUMAN, MMP15_HUMAN, MMP16_HUMAN, MMP17_HUMAN, MMP1_HUMAN, MMP2_HUMAN, MMP3_HUMAN, MMP7_HUMAN, MMP8_HUMAN, MMP9_HUMAN, MONA, MPSL1, MT-MMP 1, MT-MMP 2, MT-MMP 3, MT-MMP 4, MT1-MMP, MT2-MMP, MT3-MMP, MT4-MMP, Macrophage elastase, Macrophage gelatinase, Macrophage metalloelastase, Macrophage metaloelastase, Matrilysin, Matrilysin 2, Matrin, Matrix Metalloproteinase 26, Matrix Metalloproteinase 9, Matrix metallopeptidase 1 (interstitial collagenase), Matrix metallopeptidase 12 (macrophage elastase), Matrix metallopeptidase 13 (collagenase 3), Matrix metallopeptidase 14 (membrane inserted), Matrix metallopeptidase 15 membrane inserted, Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase, Matrix metallopeptidase 8 (neutrophil collagenase), Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), Matrix metalloprotease 1, Matrix metalloprotease 12, Matrix metalloprotease 8, Matrix metalloproteinase 17 membrane inserted, Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), Matrix metalloproteinase 3 preproprotein, Matrix metalloproteinase II, Matrix metalloproteinase-1, Matrix metalloproteinase-12, Matrix metalloproteinase-13, Matrix metalloproteinase-14, Matrix metalloproteinase-15, Matrix metalloproteinase-16, Matrix metalloproteinase-17, Matrix metalloproteinase-2, Matrix metalloproteinase-3, Matrix metalloproteinase-7, Matrix metalloproteinase-8, Membrane type 1 metalloprotease, Membrane-type matrix metalloproteinase 1, Membrane-type matrix metalloproteinase 2, Membrane-type matrix metalloproteinase 3, Membrane-type matrix metalloproteinase 4, Membrane-type-1 matrix metalloproteinase, Membrane-type-2 matrix metalloproteinase, Membrane-type-3 matrix metalloproteinase, Membrane-type-4 matrix metalloproteinase, Neutrophil collagenase, Neutrophil gelatinase, OTTHUMP00000045866, PEX, PMNL collagenase, PMNL-CL, PUMP 1, Proteoglycanase, Pump-1 protease, Putative transmembrane protein C8orf57, SL-1, SMCP-2, STMY, STMY1, Stromelisin 1, Stromelysin 1 progelatinase, Stromelysin-1, TBE-1, Transin-1, Type V collagenase, Uterine matrilysin, Uterine metalloproteinase, collagenase, fibroblast, collagenase, interstitial

Recommended products

MW 388.5 Da, Purity >98%. Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

Key facts

Purity

> 98%

PubChem identifier

132519

Biochemical name

Ilomastat

Biological description

Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

Canonical SMILES

CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC

Isomeric SMILES

CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)NC

InChI

InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1

InChIKey

NITYDPDXAAFEIT-DYVFJYSZSA-N

IUPAC name

(2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

-20°C

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